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protopathic

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protopathic /pro·to·path·ic/ (-path´ik) affected first; pertaining to sensing of stimuli in a nonspecific, usually nonlocalized, manner.
pro·to·path·ic (prt-pthk)
adj.
Sensing pain, pressure, heat, or cold in a nonspecific manner, usually without localizing the stimulus. Used especially of certain sensory nerves.
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To avoid the possibility of protopathic bias, we excluded antimicrobial drug prescriptions made during the 29 days prior to the index date.
Antimicrobial drugs and community-acquired methicillin-resistant ... by Suissa, Samy / Emerging Infectious Diseases
To reduce the risk for protopathic bias (8), we did a sensitivity analysis in which we considered any patient /// who had a recent (90-day) diagnosis of infectious diarrhea to be unexposed to fluoroquinolones.
Antimicrobial drugs and community-acquired Clostridium ... by Suissa, Samy / Emerging Infectious Diseases
The results of such observational studies often suffer from protopathic bias, in which drugs are applied to treat symptoms that are actually early manifestations of the outcome of interest (4).
Nonsteroidal antiinflammatory drugs and group A streptococcal ... by Mulla, Zuber D. / Emerging Infectious Diseases
 
 
 
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