protooncogene


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pro·to·on·co·gene

(prō'tō-on'kō-jēn),
A gene conserved long on the evolutionary scale present in the normal human genome, that appears to have a role in normal cellular physiology and is often involved in regulation of normal cell growth or proliferation; as a result of somatic mutations, these genes may become oncogenic; products of protooncognes may have important roles in normal cellular differentiation.

pro·to·on·co·gene

(prō'tō-on'kō-jēn)
A gene in the normal human genome that appears to have a role in normal cellular physiology; involved in regulation of normal cell growth or proliferation; as a result of somatic mutations, these genes may become oncogenic; products of protooncognes may have important roles in normal cellular differentiation.
References in periodicals archive ?
Multiple endocrine neoplasia type 2 RET protooncogene database: repository of MEN2-associated RET sequence variation and reference for genotype/phenotype correlations.
Protooncogene bcl-2 gene transfer abrogates Fas/APO1 antibody-mediated apoptosis of human malignant glioma and confers resistance to chemotherapeutic drugs and therapeutic irradiation.
Early alterations in ras protooncogene mRNA expression in testosterone and estradiol-17 beta induced prostatic dysplasia of Noble rats.
For example, identical nearest neighbor changes may occur at different locations in the same amplicon, such as identical base changes at multiple cysteine residues in the RET protooncogene (32).
Interestingly, the T-cell clones of both cases demonstrated vector integration near the hematopoietic protooncogene promoter of the LMO2 locus, a point insertion rate higher than would be expected with random viral integration.
The protooncogene c-kit and c-kit ligand in human disease.
Effect of peroxisome proliferators on the methylation and protein level of the c-myc protooncogene in B6C3F1 mice liver.
Neonatal exposure to high doses of the phytoestrogens equol and coumestrol is correlated with hypermethylation of a protooncogene in the rat pancreas (Lyn-Cook et al.
Thyroid hormone has been shown to regulate its own receptor, and the protooncogene c-erbA has also been identified as a thyroid hormone receptor.
7] Human genes: MEN1, multiple endocrine neoplasia 1; RET, ret protooncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease).
The HER-2/neu (HER2) (1) protooncogene (symbol ERBB2) encodes a transmembrane glycoprotein with tyrosine kinase activity that mediates proliferation and differentiation in normal epithelial cells (1).
G2/M-specific cyclin B1, cyclin-dependent kinase 1, DNA topoisomerase II alpha, c-myc protooncogene, pololike serine-threonine protein kinase, and cell division control protein 20) began on or before day 1 and peaked at some point between days 3 and 7.