proton pumps

proton pumps

Systems of enzymes that transport hydrogen ions across membranes, using energy in the process. Proton pumps that produce hydrochloric acid in the stomach derive their energy from hydrolysis of ATP.
References in periodicals archive ?
Proton pump inhibitors act by blocking the proton pumps that secrete acid in the stomach, which reduces acid levels.
In profoundly troubling studies published in 2015-2016, acid reducing drugs called proton pump inhibitors, or PPIs, were associated with an increased risk of dementia.
These H+/K+ ATPase pumps, often called proton pumps, are irreversibly inhibited by PPIs and this is the action which brings about the desired clinical effect of suppression of gastric acid secretion.
If they are used twice daily there is more chance that active proton pumps would be exposed to medicines and better acid suppression would be achieved.
PPIs by doing what they do best, inhibiting proton pumps, interfere with this acidification process that is important for cancer cell survival and growth.
This appears highly conceivable, in as much as almost all human tumours are acidic and express high levels of proton pumps.
Proton pump inhibitors (PPIs) are prescribed for severe or recurring indigestion or peptic ulcers and work by blocking the actions of proteins called proton pumps, which are partly responsible for producing stomach acid.
Osteoclasts also have proton pumps, and some researchers have suggested that PPIs have the potential to limit the activity of these proton pumps, leading to reduced bone resorption.
For most patients with chronic heartburn and regurgitation, step-down therapy to the lowest effective dose of proton pump inhibitors (PPIs) or treatment with a histamine-2 receptor antagonist (H2RA) is a reasonable, cost-effective approach.
Your child's stomach is lined with special cells that contain unique proton pumps.
Because the number of proton pumps in the stomach lining is greatest after a prolonged fast, Prevacid should be administered before the first meal of the day.
They also appear to reduce bone resorption by inhibiting osteoclastic vacuolar proton pumps.