proton pump inhibitor

inhibitor /in·hib·i·tor/ (in-hib´ĭ-tor)

1. any substance that interferes with a chemical reaction, growth, or other biologic activity.

2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.

3. an effector that reduces the catalytic activity of an enzyme.

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ACE inhibitors  angiotensin-converting enzyme i's.

alpha1-proteinase inhibitor  alpha.

angiotensin-converting enzyme inhibitors  competitive inhibitors of angiotensin-converting enzyme; used as antihypertensives, usually in conjunction with a diuretic, and also as vasodilators in the treatment of congestive heart failure.

aromatase inhibitors  a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.

C1 inhibitor  (C1 INH) an inhibitor of activated C1, the initial component of the classic complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.

carbonic anhydrase inhibitor  any of a class of agents that inhibit carbonic anhydrase activity; used chiefly for the treatment of glaucoma, and for epilepsy, familial periodic paralysis, mountain sickness, and uric acid renal calculi.

cholinesterase inhibitor  a compound that prevents the hydrolysis of acetylcholine by acetylcholinesterase, so that high levels of acetylcholine accumulate at reactive sites.

COX-2 inhibitors , cyclooxygenase-2 inhibitors a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs.

gastric acid pump inhibitor  an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.

HIV protease inhibitor  any of a group of antiretroviral drugs active against the human immunodeficiency virus, preventing protease-mediated cleavage of viral polyproteins and so causing production of immature noninfectious viral particles.

MAO inhibitor  monoamine oxidase inhibitor.

membrane inhibitor of reactive lysis  (MIRL) protectin.

monoamine oxidase inhibitor  (MAOI) any of a group of antidepressant drugs that act by blocking the action of the enzyme monoamine oxidase; believed to act by thus increasing the level of catecholamines in the central nervous system.

α2-plasmin inhibitor  α.

plasminogen activator inhibitor  (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator; the most important are PAI-1 and PAI-2.

platelet inhibitor  any of a group of agents that inhibit the clotting activity of platelets.

protease inhibitor 

1. a substance that blocks the activity of an endopeptidase (protease).

2. HIV protease i.

proton pump inhibitor  gastric acid pump i.

reverse transcriptase inhibitor  a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent.

selective serotonin reuptake inhibitor  (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used to treat depressive, obsessive-compulsive, and panic disorders.

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proton pump inhibitor

n.

A class of drugs that inhibit gastric acid secretion by interfering with the movement of hydrogen ions across cell membranes and are used mainly to treat peptic ulcers, gastroesophageal reflux disease, and esophagitis.

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Proton pump inhibitor

One of a group of drugs that acts to reduce the secretion of stomach acid.

Mentioned in: Cox-2 Inhibitors

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proton pump inhibitor,

an agent that inhibits gastric acid secretion by blocking the action of hydrogen ions, potassium ions, and adenosine triphosphatase at the secretory surface of gastric parietal cells. Also called gastric acid pump inhibitor.

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proton

an elementary particle of mass number 1, with a positive charge equal to the negative charge of the electron; a constituent particle of every nucleus, the number of protons in the nucleus of each atom of a chemical element being indicated by its atomic number.

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proton pump

see sodium pump.

proton pump inhibitor

a class of therapeutic agents which are used to counteract the effects of proton pumps in tissues and organs, particularly used in counteracting gastric hypersecretion and acidity.

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proton pump inhibitor

Pharmacology A compound–eg, Prilosec– omeprazole that is better than H2 blockers–eg, Zantac–ranitidine, Tagamet– cimetidine, for treating GERD. See Gastroesophageal reflux disease. Cf H2 blockers.