building blocks of Al tangles also differ from those of AD with the diameter of the former 2.
The released energy is then stored in the microtubule wall as an elastic strain, and the [beta]--tubulin bound GDP cannot be further phosphorylated or exchanged for GTP because the successive [alpha]--tubulin in the protofilament
occludes the preceding [beta]--tubulin nucleotide binding pocket (Heald and Nogales, 2002).
The OP-reactive tyrosine residues reside either near the GTP binding site or within loops that interact laterally with protofilaments
, indicating that this binding, if it occurs in vivo, may lead to non-cholinergic toxic outcomes (Grigoryan et al.