proto-oncogene /pro·to-on·co·gene/ (pro″to-ong´ko-jēn) a normal gene that with slight alteration by mutation or other mechanism becomes an oncogene; most are believed to normally function in cell growth and differentiation.
proto-oncogene
pro·to-on·co·gene (pr  t- ng k -j n)n. A normal gene that has the potential to transform itself into an oncogene. |
proto-oncogene
a gene that is progenitor of an oncogene.
proto-oncogene
Molecular medicine A normal gene with latent transforming potential, homologous to a retroviral oncogene Examples
c-erb, c-fos, c-jun, c-myb, c-myc, c-mos, c-raf, c-ras; POs act in normal growth, differentiation, and induction and/or maintenance of CA. See Abl, cyclin D1, RET/PTC.
c-erb, c-fos, c-jun, c-myb, c-myc, c-mos, c-raf, c-ras; POs act in normal growth, differentiation, and induction and/or maintenance of CA. See Abl, cyclin D1, RET/PTC.
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