Venous thrombosis and prothrombotic
factors in inflammatory bowel disease.
In endothelial dysfunction, there is a shift to prothrombotic
, pro-inflammatory and vasoconstrictive patterns (Kumar, 2010).
The majority usually have a detectable underlying prothrombotic
It is always mandatory to look at the underlying conditions for VTE, and in young patients, inherited prothrombotic
factors should also be evaluated, especially in case of unprovoked VTE.
Recent studies suggested that prothrombotic
mutations are genetic risk factors for cryptogenic ischemic stroke in young adults (5,6), and a relationship between prothrombotic
mutations and a risk for cerebral ischemia is present in younger PFO patients (7,8,9).
Pregnancy is a prothrombotic
state, and in studies of adult patients, HIV has also been shown to be prothrombotic
and may also be associated with deep vein thrombosis and thrombotic cerebrovascular accidents.
2) The relationship with gene-related prothrombotic
situations (especially MTHFR polymorphism) and the elevation of serum fibrinogen and homocysteine in SSNHL patients suggests a multifactorial background for microvascular events as the cause of SSNHL.
ZGN-1061 demonstrated rapid drug absorption and clearance in line with pre-specified criteria established for the molecule, and was well-tolerated and safe, with no evidence of prothrombotic
1) Patients with prothrombotic
conditions, both genetic and acquired, are at increased risk of developing CVT.
Another study (4) states that the tendency to prothrombotic
state is higher when the formation of monocyte tissue factor (TF) is increased, and prothrombin fragment [(F) 1+2] (a marker of thrombin generation in vivo) levels are elevated.
Chronic kidney disease is associated with a prothrombotic
state and progressive vascular atherosclerosis in general.
1] They also have increased levels of prothrombotic
factors (plasma plasminogen activator inhibitor-1, fibrinogen, and certain coagulation factors).