prothrombinase


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to prothrombinase: Stuart-Prower factor

prothrombinase

 [pro-throm´bin-ās]
2. the complex formed between activated factor x and calcium, phospholipid, and modified factor v; it can cleave and activate prothrombin to thrombin in the common pathway of coagulation. The term is sometimes used to refer specifically to the active enzyme center of the complex, which is activated factor x.

fac·tor X

in the clotting of blood, also known as: Stuart factor, Stuart-Prower factor, prothrombase, and prothrombinase. Its active form, factor Xa (EC 3.4.21.6), is formed from factor X by limited proteolysis and assists in the conversion of prothrombin to thrombin. A deficiency of factor X will lead to impaired blood coagulation.

prothrombinase

/pro·throm·bin·ase/ (-throm´bin-ās)
1. the complex of activated coagulation factor X and calcium, phospholipid, and modified factor V; it can cleave and activate prothrombin to thrombin.
2. sometimes specifically the active enzyme center of the complex, activated factor X.

prothrombinase

(prō-thrŏm′bə-nās′, -nāz′)
n.
An enzyme complex that catalyzes the hydrolysis of prothrombin to thrombin.

fac·tor X

(fak'tŏr)
A plasma coagulation factor that assists in the conversion of prothrombin to thrombin. Deficiency impairs blood coagulation.
Synonym(s): prothrombinase, Stuart factor, Stuart-Prower factor.

prothrombinase

; factor X blood enzyme that hydrolyses prothrombin, forming thrombin

fac·tor X

(fak'tŏr)
A plasma coagulation factor that assists in the conversion of prothrombin to thrombin.
Synonym(s): prothrombinase, Stuart factor, Stuart-Prower factor.

prothrombinase (prōthrom´binās),

n (complete thromboplastin, direct activator of prothrombin, extrinsic prothrombin activator), an inferred direct activator of prothrombin common to tissue and plasma coagulation systems. See also factor V.

prothrombinase

thromboplastin; tissue factor, factor III.
References in periodicals archive ?
2+]-induced PS exposure and MV generation by evidence of increased thrombin generation based on the prothrombinase assay and thrombin generation in plasma (Figure 4A,B).
64) In addition, we found that prothrombinase activity induced by convulxin- or collagen-related peptide, but not ionophore A23187, is directly proportional to the platelet content of GPVI (P < .
Variation in human platelet GPVI content modulates GPVI-specific prothrombinase activity.
labile factor) forms part of the prothrombinase complex, which
Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane: studies in Scott syndrome: an isolated defect in platelet procoagulant activity.
Several recent studies showed that anti-CL/[beta]2-GPI/anti-PS/PT antibodies enhance the binding of [beta]2-GPI/PT to negatively charged PL in the prothrombinase reaction (35,45-48).
After its activation by thrombin and factor Xa, activated factor V (Va) forms an essential part of the prothrombinase complex, which catalyzes the conversion of prothrombin to thrombin in the presence of calcium and a phospholipid membrane (1).
PS also has a direct effect on the assembly of both tenase and prothrombinase complexes in purified systems (8-10), but the in vivo physiologic relevance of these biological activities remains to be demonstrated.