prothrombin fragment 1.2

(redirected from prothrombin fragment 12)

pro·throm·bin frag·ment 1.2

(F1.2) (prō-throm'bin frag'mĕnt)
A peptide released when prothrombin is cleaved by factor Xa. This fragment binds to phospholipid through calcium and interacts with factor Va. Elevated plasma levels of F1.2 have been described in patients with thrombosis or in prethrombotic states.
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They found that women who had low levels of protein C, free protein S, and an-tithrombin, and high levels of D-dimer, PAP, and prothrombin fragment 12 had an elevated risk of venous thromboembolism.

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