prothrombin fragment 1.2

pro·throm·bin frag·ment 1.2

(F1.2) (prō-throm'bin frag'mĕnt)
A peptide released when prothrombin is cleaved by factor Xa. This fragment binds to phospholipid through calcium and interacts with factor Va. Elevated plasma levels of F1.2 have been described in patients with thrombosis or in prethrombotic states.
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The work-up should also include a prothrombin time/partial thromboplastin time and lupus anticoagulant profile in all of its manifestations; a measurement of protein C, S, and antithrombin III levels; a check for activated protein C resistance; as well as use of Markers of Coagulation and Hemostasis Activation (MOCHA) or your laboratory's equivalent in looking for prothrombin fragment 1.
7) studied an enzyme-linked immunosorbent assay with use of monoclonal capture antibody for prothrombin fragment 1.
Monoclonal antibodies specific for prothrombin fragment 1.

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