Other combinations currently under investigation include combining MP with the proteosome
The company notes that allowance of this patent further enhances the strategic development of a broad intellectual property estate surrounding patented core technology based upon vaccine formulations comprising Proteosome
They were able to partially restore ATRA sensitivity in the ATRA-resistant NB4 cells by proteosome
inhibitors by blocking the degradation of the fusion receptor protein.
ID Biomedical is a North American based biotechnology company focused on the development of proprietary subunit vaccine products, including those based on its Proteosome
platform intranasal adjuvant/delivery technology.
2004) and degradation of phosphorylated I-[kappa]B by the proteosome
complex (Liang et al.
Combination studies with GX15-070 demonstrated that it enhanced the anti-myeloma activity stimulated by melphalan, dexamethasone, and bortezomib, a proteosome
The phosphorylated PTEN (p-PTEN) is less susceptible to degradation by the proteosome
but is less active.
technology, which was initially invented at the Walter Reed Army Institute of Research, has been specifically designed to create nasal vaccines that elicit protective immune responses at the mucosal surfaces which line the respiratory tract including the nose, throat and lungs.
Gemin X announced today the initiation of a Phase 1/2 clinical trial of GX15-070 in combination with docetaxel (Taxotere[R]), a chemotherapeutic agent, in patients with non-small cell lung cancer (NSCLC), and a Phase 1 trial in combination with bortezomib (Velcade[R]), a proteosome
inhibitor, in patients with mantle cell lymphoma (MCL).
This is a signal in the cells for proteins such as HIF-1 a transcription factor that is constitutively expressed in the cells, but is continously degraded by ubiquitinization in the proteosomes
What is the role of proteosomes
, which remove no longer needed and even dangerous proteins (such as E2F in S phase)?
The flu vaccine is created by combining Proteosomes
with a purified preparation of influenza proteins that includes the hemagglutinin protein.