proteomics


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proteomics

(prō-tē-om'iks),
The identification and study of the proteins of a cell, tissue, or organism to determine their three-dimensional structure and to map their interactive networks to discover their function and the structure of drugs with the potential to interact in a therapeutic way with disease-associated proteins; goal is not only formulation of new drugs but also diagnostics and determining the presence of or absence of specific proteins associated with a disease or health.
See also: proteome, proteome image.

proteomics

(prō′tē-ō′mĭks)
n.
(used with a sing. verb) The analysis of the expression, localizations, functions, and interactions of the proteins expressed by the genetic material of an organism.

proteomics

The study of the proteome-the proteins expressed by the approximately 22,000 genes in the GENOME or by a cell. The form and quantity of the proteins produced by a cell cannot be fully predicted from DNA or RNA analysis alone. This is because of the controls and the many modifications that can occur in the stages between transcription and protein formation. Thus the totality of the genes can result in at least several hundred thousand different proteins. Proteomics includes the study of the factors that cause this multiplication. The discipline is being applied effectively to cancer studies.

proteomics

characterization of the PROTEOME by cataloguing and analysing the proteins. This involves:
  1. (a) identifying each protein in the proteome;
  2. (b) determining the sequence (see AMINO-ACID SEQUENCE of the proteins and constructing a database;
  3. (c) determining the amount of protein in different cell types and at different stages of development and
  4. (d) investigating the interactions between proteins.

proteomics

the comprehensive analysis of the identity, interactions and locations of proteins within a cell.
References in periodicals archive ?
Functional proteomics technologies include yeast two-hybrid system for studying protein- protein interactions.
Proteomics is the study of the structure and function of proteins and how they interact within a complex biological system.
This book is aimed clearly at those wishing to understand what current proteomics technology can do for biomedical research.
Through these collaborations, Applied Biosystems gets its 4700 Proteomics Analyzer into laboratories and expands applications for the platform.
The Staccato Proteomics System provides a key interface to GeneProt's industrial scale proteomics processes.
In addition, the book includes extensive references and a list of relevant proteomics information sources.
Consequently, proteomics is a dynamic, challenging research area.
A major advantage of the proteomics approach is that it can identify disease-related proteins whose very existence may not have previously been suspected.
This book provides a highly authoritative introduction to the promising and fast-advancing field of proteomics, examining the role proteomics plays in the study of biological systems in general and disease in particular.
The application of proteomics tools in the clinical setting lags far behind their use in basic science and drug discovery.
With the completion of the Human Genome Project, it has become apparent that the field of proteomics research holds tremendous promise for cancer research, including the discovery of molecular markers for early diagnosis, identifying novel protein drug targets for new anticancer drug development, and revealing new endpoints for accelerating clinical trials.