proteomics

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Related to proteomic: Metabolomics

proteomics

(prō-tē-om'iks),
The identification and study of the proteins of a cell, tissue, or organism to determine their three-dimensional structure and to map their interactive networks to discover their function and the structure of drugs with the potential to interact in a therapeutic way with disease-associated proteins; goal is not only formulation of new drugs but also diagnostics and determining the presence of or absence of specific proteins associated with a disease or health.
See also: proteome, proteome image.

proteomics

(prō′tē-ō′mĭks)
n.
(used with a sing. verb) The analysis of the expression, localizations, functions, and interactions of the proteins expressed by the genetic material of an organism.

proteomics

The study of the proteome-the proteins expressed by the approximately 22,000 genes in the GENOME or by a cell. The form and quantity of the proteins produced by a cell cannot be fully predicted from DNA or RNA analysis alone. This is because of the controls and the many modifications that can occur in the stages between transcription and protein formation. Thus the totality of the genes can result in at least several hundred thousand different proteins. Proteomics includes the study of the factors that cause this multiplication. The discipline is being applied effectively to cancer studies.

proteomics

characterization of the PROTEOME by cataloguing and analysing the proteins. This involves:
  1. (a) identifying each protein in the proteome;
  2. (b) determining the sequence (see AMINO-ACID SEQUENCE of the proteins and constructing a database;
  3. (c) determining the amount of protein in different cell types and at different stages of development and
  4. (d) investigating the interactions between proteins.

proteomics

the comprehensive analysis of the identity, interactions and locations of proteins within a cell.
References in periodicals archive ?
Proteomic technologies are now being integrated into the drug discovery process as complimentary to genomic approaches.
SomaLogic's cutting-edge proteomic technology makes them an ideal partner for us to increase our presence in this growing market.
The validation of a direct mass spectrometric analysis was a major advance in area of proteomic tissue analysis (7-8).
5 million in funding over five years for five Clinical Proteomic Technology Centers for Cancer Research (CPTAC).
Further, it plans to improve the device in collaboration with researchers engaged in proteomic analysis.
Each has several chapters written by experts who review the literature and discuss current advantages of proteomic research.
High-resolution serum proteomic features for ovarian cancer detection.
A preeclampsia proteomic biomarker score was assigned to each specimen.
This novel technology enables proteomic life science researchers to gain greater automation capabilities, improved sensitivity and contamination free processing," notes David Miller, Proteomic Global Product Manager.
Analysis of different levels of gene expression in healthy and diseased tissues by proteomic approaches is as important as the detection of mutations and polymorphisms at the genomic level and may be of more value in designing a rational therapy.
Proteomics of human body fluids; principles, methods, and applications.
Surface-enhanced laser desorption/ionization (SELDI) ProteinChip technology is a proteomic tool that has been applied to the discovery of diagnostic proteomic signatures in the sera of patients with various diseases, including cancer and infectious diseases (18, 21, 22 ).