proteoglycans


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Related to proteoglycans: fibronectin

proteoglycans

Bimolecule complexes of proteins and GLYCOSAMINOGLYCANS with a high proportion of carbohydrate (up to 96 per cent) to protein. They are structural components of connective tissues and lubricants, help in the adhesion of cells to the extracellular matrix, and bind factors that promote cell proliferation.

proteoglycans (prō´tēōglī´kans),

n.pl the mucopolysaccharides bound to protein chains occurring in the extracellular matrix of connective tissue.
References in periodicals archive ?
OUMS-27 cell line secretes cartilage-specific proteoglycans, and type-2 and -9 collagens.
Small leucine-rich proteoglycans (SLRPs) are ECM proteoglycans required for collagen fibrillogenesis.
The Safranin O staining showed a significantly different proteoglycan profile between the CON group and the injury groups.
5 and 1%) solution of proteoglycan extracted from nasal cartilage of Oncorhynus keta (Salmon) having property like epidermal growth factor was used as a positive control.
Aside from water, which comprises 70-80% of human cartilage, collagen and proteoglycans are its major components, each assuming 10-20% of the avascular glossy covering of the underlying subchondral bone, followed by the chondrocytes, which produce and maintain the cartilage ECM and comprise 1-5% of it.
In osteoarthritis, early proteoglycan loss leads to expansion of the residual proteoglycans and increased cartilage water content, which may appear as increased cartilage thickness on MRI.
Proteoglycans are an important component in the extracellular matrix, and they form large complexes by linking with other proteoglycans and molecules such as hyaluronic acid (hyaluronan) and collagen.
Glycomics is the analysis of the structure and functions of glycans or oligosaccharides (chains of sugars) attached to biomolecules and includes the analysis of glycoproteins, proteoglycans, glycolipids, peptidoglycans, and lipopolysacchrarides.
Syndecan-2 is but one member of the syndecan family of heparan sulfate proteoglycans.
Furthermore, studies have demonstrated that small, dense LDL particles penetrate more easily into the arterial intima (1), exhibit increasing binding to arterial wall proteoglycans (2), and are more prone to oxidative stress (3).
The extracellular matrix (ECM) is composed of a great variety of molecules and includes collagen family, elastic fibers, glycosoaminoglycans and proteoglycans, and adhesive glycoproteins.
They will develop insight into the mechanisms of post-mortem meat degradation; identify and characterize proteins and proteoglycans that influence product quality; and characterize and quantify microstructure and important components both in the raw material and end product.