biglycan

(redirected from proteoglycan I)

bi·gly·can

(bī'glī-kan), [MIM*301870]
A small interstitial proteoglycan that contains two glycosaminoglycan chains.
Synonym(s): proteoglycan I

biglycan

A small leucine-rich repeat (LRR) proteoglycan encoded by BGN on chromosome Xq28, which plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex.

biglycan

a small chondroitin sulfate proteoglycan found in mineralized bone.
References in periodicals archive ?
Evidence from other studies suggests loss in proteoglycan is perhaps the earliest osteoarthritis-induced change in cartilage.