protein-tyrosine kinases


Also found in: Dictionary.

protein-tyrosine kinases

A large class of enzymes that catalyse the transfer of phosphate from ATP to tyrosine residues in polypeptides. Their products regulate cell proliferation, survival, differentiation, function and motility. These enzymes are regarded as excellent targets for cancer chemotherapy. Drugs such as imatinib mesylate inhibit these enzymes.
References in periodicals archive ?
Receptor protein-tyrosine kinases and their signal transduction pathways.
The gene involved in X-linked agammaglobulinemia is a member of the src family of protein-tyrosine kinases.
Southern blot analysis of DNA from pedigrees with XLA cases showed restriction fragment length alterations that segregated in an X-linked recessive pattern; detailed analysis disclosed either genomic DNA deletions in the region encompassing Btk or missense point mutations resulting in nonconservative amino acid substitutions at important residues in the putative protein-tyrosine kinase domain (89).
The agent's high selectivity for inhibiting retroviral protein-tyrosine kinases suggests it may also be useful for non-AIDS retroviruses, including those associated with herpes, hepatitis, and the Ebola virus.

Full browser ?