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Etymology: Gk, proteios, first rank; L, sentire, to feel
a reaction that follows parenteral introduction of a foreign protein into the body. Symptoms of varying severity, including serum sickness, occur when the same foreign protein is reintroduced into the body at a later date.
Sensitization as a result of previous injection of a foreign protein into the body.
See also: sensitization
a state in which the body is sensitized to particular stimuli, e.g. (1) certain individuals exposed to some antigens by a particular route elicit an immune response which may be antibody-mediated, particularly IgE, or cell-mediated which sensitizes them such that subsequent exposure to the same antigen elicits an allergic response; said especially of such exposure resulting in a hypersensitivity reaction. (2) The coating of cells with antibody as a preparatory step to some detectable reaction such as their lysis if complement is added. (3) The preparation of a tissue or organ by one hormone so that it will respond functionally to the action of another.
that bodily state in which the individual is sensitive or hypersusceptible to some foreign protein, so that when there is absorption of that protein a typical reaction is set up.