protein phosphatases


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pro·tein phos·pha·tas·es

a class of enzymes that catalyze the dephosphorylation of specific phosphorylated proteins.
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Together with protein phosphatase 2A, Cn is normallyresponsible for the dephosphorylation of [tau] protein.
Blockade of protein phosphatase 2B activity in the amygdala increases anxiety- and depression-like behaviors in mice.
Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/[beta]-catenin pathway activity.
Protein phosphatase 1 is a molecular constraint on learning and memory.
The inhibitory effect of AMP-dependent protein kinase (32-34) is counteracted by protein phosphatase 2A activity (35-37).
The second factor was based on the finding that since microcystin is covalently bound to protein phosphatase 1 and protein phosphatase 2A, as much as 80% of the MCYST exposure might not be recognized by the ELISA assay (21,22).
Hepatocytes deformation induced by cyanobacteria toxins reflects inhibition of protein phosphatases.
Targeting protein phosphatases is an emerging field with a lot of the research being done for the development of novel anti-cancer therapeutics.
PHILADELPHIA -- The leading industry and academic researchers in the field of protein phosphatases will convene this fall at a new conference entitled, "Protein Phosphatases as Therapeutic Targets", which will take place in Philadelphia on September 26-27, 2002, announces Strategic Research Institute.
The data were presented at the Federation of American Societies for Experimental Biology (FASEB) Summer Conference on Protein Phosphatases in Copper Mountain, Colorado.
Calcineurin is an enzyme and a member of a family of cell signal- transduction proteins called serine/threonine protein phosphatases that regulate a variety of cell functions including DNA replication, gene activation, cell cycle and cell growth, response to hormones, and transformation of cells into tumors.

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