Preclinical messenger RNA data in cell and rodent models with cystic fibrosis transmembrane conductance, tumor protein p53
, alpha-1 antitrypsin, factor IX, and erythropoietin demonstrate rapid protein production
For example, TP53 (tumor protein p53
, also known as p53)  signatures are present in 25% of tubal epithelium samples in healthy controls (3).
Gene p53 mutations, protein p53
, and anti-p53 antibodies as biomarkers of cancer process.
In particular, several proteins involved in DNA damage signaling and repair, replicative enzymes such as DNA and RNA polymerases and transcription factors such as tumour protein p53
(17), require zinc for proper functions (18-20).
Washington, Nov 25 (ANI): Cancer biologists have revealed that restoring the gene for cancer protein p53
could slow the spread of advanced lung tumours, but doesn't help early-stage cancers.
The compound works by freeing up the cancer-fighting protein p53
, which gets bogged down in patients with neuroblastoma and other cancers.
investigated the correlation links between expression level of protein p53
, p21(WAF1/CIP1), p16 (INK4) and proliferative potential in human endometrial adenocarcinoma (EC).
Furthermore, they go on to show that VDR is not required for UVB-induced upregulation of protein p53
and activity, since increases in p53 were detected in VDR knockout mice.
The DNA-binding capacity of the tumor suppressor protein p53
is impaired by Cd(II), Ni(II), and Co(II) (Meplan et al.
Scientists led by Lawrence Donehower, at Baylor College of Medicine in Houston, Texas, boosted levels of the cancer-preventing protein p53
in genetically-modified mice.
The kit targets multiple genes, including TP53 (tumor protein p53
gene, located on chromosome 17p) within the del17p region, and is used as an aid for determining prognosis for patients with CLL.
PUMA is activated by tumour-suppressor protein p53
, also called 'the guardian of the genome'.