TTLL8

(redirected from protein monoglycylase TTLL8)

TTLL8

A gene on chromosome 22q13.33 that encodes a monoglycylase which generates side chains of glycine on specific glutamate residues of target proteins. TTLL8 monoglycylates tubulin, with a preference for alpha-tubulins over beta-tubulins. It also monoglycylates non-tubulin proteins such as ANP32A, ANP32B, SET and NCL.