protein misfolding disease

protein misfolding disease

Any abnormality that prevents a polypeptide chain from achieving its usual structure in the body, rendering it functionally abnormal or inactive. Examples include sickle cell disease, in which a single genetic substitution makes hemoglobin molecules distorted under low oxygen tension, or Alzheimer's disease, in which structurally abnormal amyloid plaques build up in the brain, causing dementia.
References in periodicals archive ?
The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.
Buhimschi and her team had found in an earlier study that preeclampsia is a pregnancy-specific protein misfolding disease.
These results support the hypothesis that preeclampsia is a pregnancy-specific protein misfolding disease.
Familial ALS caused by mutations in the SOD1 gene is a particularly well-characterized example of a neurodegenerative protein misfolding disease.
About CogRx Cognition Therapeutics is a privately held Pittsburgh-based pharmaceutical company using disease-relevant screening and novel chemistry platform approaches to produce a pipeline of new small molecule drug candidates for protein misfolding diseases of the nervous system.
Another 29 reviews consider such topics as mechanisms of acid resistance in Escherichia coli, microbial contributions to phosphorus cycling in eutrophic lakes and wastewater, wall teichoic acids of Gram-positive bacteria, biological consequences and advantages of asymmetric bacterial growth, prions and the potential transmissibility of protein misfolding diseases, and the wonderful world of archaeal viruses.
Proteins associated with protein misfolding diseases, incuding neurodegenerative diseases such as Alzheimer~s, undergo conformational changes such as the transformation of largely random coiled or A-helix structures to the highly ordered A-structures found in protein fibrils.
We wanted to uncover general principles that could be applied to a variety of loss-of-function protein misfolding diseases.
He serves on the board of Adlyfe, a company specializing in protein misfolding diseases.
We strongly believe our GAIM approach has tremendous development opportunity across multiple protein misfolding diseases and could significantly improve the lives of patients and their caretakers.
This suggests that inhibition of PPP1R15A could ameliorate protein misfolding diseases.
FoldRx has developed an innovative approach to the treatment of protein misfolding diseases and amyloidosis and this is a pivotal time for the company as its lead product, Fx-1006A, advances through clinical development for treatment of TTR amyloidosis," noted Mr.