protein kinase


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Related to protein kinase: Protein kinase C, Protein kinase B

protein kinase

/pro·tein ki·nase/ (pro´tēn ki´nās) an enzyme that catalyzes the phosphorylation of serine, threonine, or tyrosine groups in enzymes or other proteins, using ATP as a phosphate donor.

protein kinase

n.
Any of a group of kinases that phosphorylate the amino acids serine, threonine, and tyrosine in certain proteins, that regulate essential aspects of cell growth and movement, and that can cause cancer and other diseases when dysfunctional.

protein kinase (PKA)

a protein that catalyzes the transfer of a phosphate group from adenosine triphosphate to produce a phosphoprotein.

protein kinase

This name was officially retired in 2005; however, although the term is nonspecific, it is still in common use. It is now formally divided into:
• EC 2.7.11.1, non-specific serine/threonine protein kinase;
• EC 2.7.11.8, Fas-activated serine/threonine kinase;
• EC 2.7.11.9, Goodpasture antigen-binding protein kinase;
• EC 2.7.11.10, IκB kinase;
• EC 2.7.11.11, cAMP-dependent protein kinase;
• EC 2.7.11.12, cGMP-dependent protein kinase;
• EC 2.7.1.13, protein kinase C;
• EC 2.7.11.21, polo kinase;
• EC 2.7.11.22, cyclin-dependent kinase;
• EC 2.7.11.24, mitogen-activated protein kinase;
• EC 2.7.11.25, mitogen-activated protein kinase kinase kinase;
• EC 2.7.11.30, receptor protein serine/threonine kinase; and
• EC 2.7.12.1, dual-specificity kinase.

protein kinase

an ENZYME that catalyses the transfer of a phosphate group from ATP to an AMINO ACID in a PROTEIN. In this way, the activity of enzymes can be decreased or increased. By thus altering proteins, kinases are thought to be important in mediating various processes in the CELL.
References in periodicals archive ?
Scientists have known for many years that the well-studied vaccinia poxvirus uses two proteins to inhibit the protein kinase R response.
Other reported skin reactions seen in conjunction with protein kinase inhibitor therapy include skin rashes, pruritus, blistering, peeling skin, hand-foot skin reaction, and difficulties with wound healing.
In connection with the use claims where protein kinase N beta as such (or antibodies, spiegelmers, aptamers, ribozymes, antisense molecules and siRNA molecules directed against protein kinase N beta and the nucleic acid molecule coding therefore, respectively) are used for the manufacture of a medicament, the diseases for which such medicament is to be used are now restricted to metastatic cancers.
The downside is that by promoting cell survival, protein kinase D can enable skin cells with a lot of DNA damage to become cancerous by reducing the natural ability of badly damaged skin cells to self-destruct, the researchers show.
In the present study allostery was revealed in the protein kinase A catalysed reaction of peptide phosphorylation, and the effect was quantified in terms of the interaction factor [alpha] for seven substrates.
Modulation of tumor necrosis factor-alpha and oxidative stress through protein kinese C and P42/44 mitogen-activated protein kinase in lead increases lipopolysaccharide-induced liver damage in rats.
We feel that the PLK1-B23 phosphorylation story nicely demonstrates the power of the Kinetworks(TM) approach to rapidly and cost-effectively discover protein kinase drug targets and the means to identify their inhibitors" said Dr.
This approach was practically tested for protein kinase A reaction with its specific peptide substrate LRRASLG (Kemptide) [10].
HIV-1 gp120 and chemokine activation of pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling.
Scope - DelveInsight's report provides a Protein Kinase C Beta (PKC-Beta) Inhibitors Landscape across the globe - The report provides drug profiles which includes product description, MOA, licensors & collaborators, technology, development partner and chemical information - Coverage of the Protein Kinase C Beta (PKC-Beta) Inhibitors pipeline on the basis of target, MOA, route of administration, technology involved and molecule type - The report reviews key players involved in the therapeutics development for Protein Kinase C Beta (PKC-Beta) Inhibitors and also provide company profiling - Pipeline products coverage based on various stages of development from NDA filings to discovery.
The gene IKKE produces a protein kinase also known as IKKE.

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