protein inhibitor of activated STAT1

protein inhibitor of activated STAT1

A protein encoded on chromosome 15q that inhibits STAT1-mediated gene activation and DNA-binding activity; binds to Gu protein/RNA helicase II/DEAD box polypeptide 21; and interacts with androgen receptor (AR). It plays a key role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone-signalling pathway. It acts in the testis as a nuclear receptor transcriptional coregulator, and may have a role in AR initiation and maintenance of spermatogenesis.
Full browser ?