glycosylation

(redirected from protein glycosylation)
Also found in: Dictionary, Encyclopedia.

glycosylation

 [gli-ko″-sĭ-la´shun]
the formation of linkages with glycosyl groups.

gly·co·sy·la·tion

(glī'kō-si-lā'shŭn),
Formation of linkages with glycosyl groups, as between d-glucose and the hemoglobin chain to form the fraction hemoglobin AIc, the level of which rises in association with the elevated concentration of d-glucose in blood concentration in poorly controlled or uncontrolled diabetes mellitus.
See also: glycosylated hemoglobin.

glycosylation

/gly·co·syl·a·tion/ (gli-ko″sĭ-la´shun) the formation of linkages with glycosyl groups.

glycosylation

(glī′kō-sĭ-lā′shən)
n.
The addition of saccharides to proteins or lipids to form a glycoprotein or glycolipid.

gly·co′sy·late′ v.

glycosylation

[glīkə′səlā′shən]
the formation of linkages with glycosyl groups, covalently attaching a carbohydrate to another molecule.

gly·co·sy·la·tion

(glī'kō-si-lā'shŭn)
Formation of linkages with glycosyl groups, as between d-glucose and the hemoglobin chain to form the fraction hemoglobin AIc, the level of which rises in association with the raised blood d-glucose concentration in poorly controlled or uncontrolled diabetes mellitus.
See also: glycosylated hemoglobin

glycosylation

the addition of a CARBOHYDRATE to an organic molecule such as a PROTEIN.

glycosylation (glī·kōˈ·s·lāˑ·shn),

n process in which a carbohydrate is covalently attached to another molecule.

glycosylation

the formation of linkages with glycosyl groups.

N-linked glycosylation
attachment of oligosaccharides, synthesized on a dolichol-lipid platform to proteins through the amino acid asparagine spaced close to threonine or serine in the polypeptide sequence.
O-linked glycosylation
attachment of groups of oligosaccharides directly to proteins through the hydroxyl group of threonine.
References in periodicals archive ?
Recent advances in chromatographic approaches are leading to better resolution, sensitivity, and speed during the qualitative and quantitative analysis of protein glycosylation.
Our studies were mainly based on glycosidase digestion followed by SDS-PAGE and Western analysis, a classic approach to analyze protein glycosylation.
Cellectis' innovative nucleases have the potential to enable the modification of protein glycosylation patterns in plants with unprecedented control and uniformity, allowing for increased efficacy of therapeutic products.
The E protein glycosylation motif previously identified in lineage 1 at positions 154-156 (NYS)(6) was present in all 4 South African strains.
A female patient with cystic fibrosis showed high %CDT as well as a type 2 Tf-IEF profile, supporting the hypothesis that altered function of cystic fibrosis transmembrane conductance regulator (CFTR) affects the compartmentalization of glycosyltransferases in the Golgi, thereby disturbing protein glycosylation (39).
Analysis of protein glycosylation is a demanding task that has often been reserved for specialized laboratories," said Nicolle Packer, executive vice president and head of glycoproteomics of Proteome Systems.
The most successful of these approaches has been chemical conjugation with monomethoxypolyethylene glycol (PEG), amino acid engineering leading to altered protein glycosylation and the addition of non-biologically active "carrier" domains.
Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.
Neose's Vice President, New Product Development, said "We are looking forward to having Victor help us move ahead with commercializing GlycoAdvance, our program for protein glycosylation.
Carbohydrate-deficient glycoprotein syndromes: inborn errors of protein glycosylation.
The agreement also involves a multi-year collaborative research program focused on further optimizing protein glycosylation in transgenic plant systems.