protein folding


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protein folding

The shaping of a protein into its unique three-dimensional conformation from the linked amino acids of which it is composed.

protein folding

The process by which proteins acquire their normal, energetically-favourable, three-dimensional form. The folding has long been believed to be specified by the amino acid sequence, but recent research suggests that proteins may fold into abnormal shapes by mechanisms not yet determined. Abnormal folding results in loss of normal protein function but also in proteolytic degradation and the accumulation of fragments that form insoluble plaques in the various organs including the brain and the liver. This is believed to be the way in which the characteristic plaques and fibrillary tangles of ALZHEIMER'S DISEASE occur.
References in periodicals archive ?
Chaperone's therapeutic approaches elevate the natural protein folding and stress protection mechanisms to prevent protein misfolding and the ensuing neuronal cell death.
The HP lattice model recognises only the hydrophobic interaction as the driving force in protein folding, with many native structures protecting the hydrophobic core with polar residues, resulting in a compact arrangement [11].
Blue Gene will allow IBM to learn about complex computer architectures, self-healing systems and large-scale computer simulations of such activities as protein folding.
com/research/8fpb5s/protein_folding) has announced the addition of Woodhead Publishing Ltd's new book "Protein folding in silico: Protein folding versus protein structure prediction" to their offering.
Proper protein folding has long been recognized as a process that is essential to all organisms.
Five examples include mental disorders, protein folding, and glycome determinants.
By bringing together world-leading scientists in conotoxin pharmacology and protein folding, this project will develop excellent scientific and leadership competences at a high level for a young talented European scientist.
8220;Our understanding of protein folding inside the cell has advanced significantly over the last two decades.
Now, a team at Universite de Montreal has shown that a technique based on the fluorescence of tryptophan might be a better tool to probe protein folding than anyone previously thought.
Sony and Stanford University's Folding@home project have created an application that breaks huge processing tasks into smaller units, also known as distributed computing, thereby allowing Playstation 3 owners to donate extra processing power to scientists studying protein folding.
Without the power of protein folding, activity, in any cell would quickly come to a halt.