seborrhoea-like dermatitis with psoriasiform elements

(redirected from protein ZNF750)

seborrhoea-like dermatitis with psoriasiform elements

An inherited condition (OMIM:610227) characterised by a chronic fine diffuse scaly erythematous rash on the face, especially of the chin, nasolabial folds, eyebrows, around the earlobes and over the scalp, that exacerbates in the winter, with emotional stress and after strenuous physical activity. It is accompanied by hyperkeratosis over the elbows, knees, palms, soles and metacarpophalangeal joints.

Molecular pathology
Defects in ZNF750, which encodes a zinc finger protein transcription factor involved in epidermis differentiation, cause seborrhoea-like dermatitis with psoriasiform elements.
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