S100A4

(redirected from protein S100-A4)

S100A4

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A4-encoded protein is thought to play a role in motility, invasion and tubulin polymerisation.
 
Molecular pathology
S100A4 rearrangements have been implicated in tumour metastasis.
References in periodicals archive ?
Notably, two of the downregulated proteins, protein S100-A4 (S100A4) and laminin-binding protein (RPSA) are known to play key roles in driving metastasis and were verified using Western blotting.
Rabbit monoclonal antibodies against protein S100-A4 (S100A4) (ab124805) and laminin-binding protein (RPSA) (ab133645) were purchased from Abeam (Cambridge, UK).
For the detection of protein S100-A4 (S100A4), 12% Tris-Tricine SDS-PAGE was used instead to separate the protein samples.