protein C deficiency


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protein C deficiency

A condition characterized by a deficiency of vitamin K dependent plasma protein C and protein S, both natural anticoagulants; PCD is either AD of variable penetration, or acquired, and due to DIC, warfarin therapy, hepatic disease and postoperatively
References in periodicals archive ?
5, 6] Incidence of clinically symptomatic protein C deficiency lies between 1:16, 000 to 1:32 000 persons while that of symptomatic protein S deficiency is 1:20,000.
CONCLUSION: We conclude that, the frequency of protein C deficiency, protein S deficiency and hyperhomocysteinemia are significantly higher among those with thrombogenic events than general population and hence need to be screened for in all thrombogenic events.
The clinical spectrum of heterozygous protein C deficiency in a large New England kindred.
Reported causes of thrombophilia in HIV-infected subjects include antiphospholipid syndrome [1], increased platelet activation [1], elevated homocysteinemia [2], elevated plasma factor VII activity [2], lupus anticoagulant [3], activated protein C resistance [3], protein C deficiency [3,4], and acquired protein S deficiency [4-10].
Isolated protein S deficiency was seen in 9 patients, and combined protein S plus protein C deficiency occurred in 3 subjects.
These protein deficiencies/abnormalities are genetic and include entities such as antithrombin deficiency, protein C deficiency, protein S deficiency, Factor V Leiden mutation, prothrombin 20210, and dysfibrinogenemia, among others.
A case of purpura fulminans secondary to transient protein C deficiency as a complication of chickenpox infection.
Protein C deficiency was first reported in 1981 by Griffin et al.
However, genetic testing has been used successfully for prenatal diagnosis of homozygous protein C deficiency.
Primary hypercoagulable states involve specific abnormalities of hemostasis and include antithrombin III deficiency, protein C deficiency, protein S deficiency, lupus anticoagulant, disorders of fibrinolytic system (eg, disorders of tissue plasminogen activator, abnormal plasminogen and hypoplasminogenemia), dysfibrinogenemia factor XII deficiency, and anticardiolipin antibody syndrome.
Whereas the incidence of asymptomatic heterozygous protein C deficiency in the general population is approximately 1 in 200, the true incidence of protien S deficiency is currently unknown.
ProC Global represents an easy-to-perform screening test that is highly sensitive for FV Leiden and protein C deficiency.