protein 4.1(redirected from protein 41)
a peripheral protein that binds tightly to spectrin in the red blood cell membrane; it also binds to certain glycophorins and helps determine the shape and flexibility of the red blood cell.
EPB41A gene on chromosome 1p33-p32 that encodes protein 4.1, which, with spectrin and actin, constitutes the red cell membrane cytoskeletal network. This network plays a critical role in red cell shape and deformability.
EPB41 mutations cause elliptocytosis type 1.