protective antigen


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.

protective antigen

The protein made by Bacillus anthracis, which binds to cell membranes and allows the lethal components of anthrax toxin to enter and kill cells.
See also: antigen
References in periodicals archive ?
The expression of the protective antigen of Bacillus anthracis in Bacillus subtilis.
Emergent is also working on a next generation of vaccines that stimulate the immune response to protective antigen as well as a monoclonal antibody treatment.
In DNA vaccination, the injected plasmid DNA molecules believed to enter nucleus actively and remain in side the nucleus as episomal DNA lifelong, thus generating the protective antigens continuously as long as the cell lives (7).
Expression of Bacillus anthracis protective antigen in transgenic chloroplasts of tobacco, a non-food/feed crop.
In order to express foreign protective antigen in attenuated S.
The investigational antibody is designed to target a protein component known as the anthrax protective antigen (PA) of the lethal toxin complex produced by the bacterium.
One of the proteins, called protective antigen (PA), acts as the scout, latching on to a cell.
This diagnosis was supported by seroconversion to protective antigen of Bacillus anthracis and the presence of antibodies against lethal factor.
In addition, the vaccine candidate for disease caused by anthrax bacilli may provide a safer and better anthrax vaccine based on a recombinant protective antigen.
A greater than fourfold rise from baseline in the concentration of immunoglobulin G to protective antigen was demonstrated.
But scientists at Porton Down, who tested blood samples from five Scots victims, said two tested positive for the main anthrax toxin, Protective Antigen.
The British vaccine is similar to this and both immunise against a protein in anthrax toxin called protective antigen.