protease


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Related to protease: Protease inhibitors

endopeptidase

 [en″do-pep´tĭ-dās]
any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein. Inhibition of the action of endopeptidases (proteases) in viruses causes formation of noninfectious particles; certain antiviral drugs work in this way (see protease inhibitors). Called also protease and proteinase.

pro·te·ase

(prō'tē-āz),
Descriptive term for proteolytic enzymes, both endopeptidases and exopeptidases; enzymes that hydrolyze (break) polypeptide chains.

protease

/pro·te·ase/ (pro´te-ās) endopeptidase.

protease

(prō′tē-ās′, -āz′)
n.
Any of various enzymes, including the endopeptidases and exopeptidases, that catalyze the hydrolytic breakdown of proteins. Also called peptidase.

protease

[prō′tē·ās]
an enzyme that is a catalyst in the breakdown of peptide bonds that join the amino acids in a protein. See also proteolysis.

pro·te·ase

(prō'tē-ās)
Descriptive term for proteolytic enzymes, both endopeptidases and exopeptidases; enzymes that hydrolyze (i.e., break) polypeptide chains.

protease

One of a range of protein-splitting enzymes. One focus of current interest in proteases is in their role in breaking down tissue barriers in the spread of cancer. High concentrations of the activator of one of these proteases has been found to be associated with a poor outlook in cancers of the colon and rectum.

protease

any enzyme that splits proteins, such as PEPSIN, TRYPSIN, EREPSIN or RENNIN.

protease

; proteinase enzyme that breaks down/proteolyses protein

protease

any proteolytic enzyme.

protease-antiprotease imbalance
thought to play a part in the pathogenesis of emphysema by permitting excessive proteolysis, especially of elastin.
fecal protease
originate from the pancreas and include trypsin, chymotrypsin and carboxypeptidases. Proteolytic activity of the feces may be evaluated by tests that measure digestion of gelatin or casein-based substrates.
α1-protease inhibitor
α1-antitrypsin.
References in periodicals archive ?
In vitro assays have shown that DP100 does not degrade phytase, in fact, the protease benefit is maintained even when superdosing phytase.
The study from Ramsar hot spring, two samples with high protease activity (code c2, zh5) was isolated.
A research team led by Dieter Jenne at the Max Planck Institute of Neurobiology in Martinsried has come across a previously unknown protease in humans: neutrophil serine protease 4, or NSP4.
Measurement of protease activity: In this 1 ml of the enzyme solution was added to 1 ml casein solution (1%, w/v casein solution prepared in 50 mM Glycine-NaOH buffer, pH 11) and incubated at 35[degrees]C for 20 min.
Avila has used its proprietary Avilomics platform to design covalent irreversible protease inhibitors that are highly selective, potent and with superior duration of action as compared to conventional protease inhibitors.
Certain facets of this organism are clearly highly dependent on cysteine proteases," says parasitologist Edward J.
The HIV protease inhibitor project is valued atEUR 64m, of which EUR 2m is a license fee due on signing of the agreement.
Shortly after approval, the price was set at $25 a day (wholesale acquisition price)--at the low end of the last three protease inhibitors approved (the ritonavir will cost extra).
Results from the first-generation protease inhibitor--saquinavir, ritonavir (Norvir), and indinavir (Crixivan)--combination studies were greeted with much excitement as they showed a profound effect on survival and ability to control virus replication.
The hemagglutinin glycoprotein is produced as a precursor, HA0, which requires posttranslational cleavage by host proteases before infectious virus particles can be produced (3).
Of 3,247 patients seen in HIV clinics between 1993 and 2002 who were treated with protease inhibitors, 19 experienced MI, compared with only 2 of 2,425 who were not treated with protease inhibitors.