protamine (redirected from protamine zinc insulin (PZI))

protamine /pro·ta·mine/ (prōt´ah-min) one of a class of basic proteins occurring in the sperm of certain fish, having the property of neutralizing heparin; the sulfate salt is used as an antidote to heparin overdosage.

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pro·ta·mine (prt-mn, -mn) or pro·ta·min (-mn)

n.

Any of a group of simple proteins found in fish sperm that are strongly basic, are soluble in water, are not coagulated by heat, and yield chiefly arginine upon hydrolysis. In purified form, they are used in a long-acting formulation of insulin and to neutralize the anticoagulant effects of heparin.

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protamine [pro´tah-min]

any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol. Protamines neutralize heparin, and protamine sulfate is used as an antidote in heparin overdosage, administered intravenously.

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protamine

any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol, found combined with nucleic acids in the sperm of certain fish, and having the property of neutralizing heparin. Protamine sulfate is used as an antidote to heparin overdosage.

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protamine paracoagulation

used to examine a blood sample for fibrin monomers and fibrinogen-split products.

protamine zinc insulin (PZI)

see insulin.