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protamine sulfate

   Also found in: Wikipedia 0.01 sec.
protamine sulfate
[prō′təmēn]
a heparin antagonist derived from fish sperm.
indication It is prescribed to diminish or reverse the anticoagulant effect of heparin, particularly in cases of heparin overdosage.
contraindications Pregnancy, allergy to fish, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are hypotension, dyspnea, and bradycardia. Dosage greater than needed to neutralize heparin causes the toxic and anticoagulant effects of protamine.


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Protamine sulfate, a heparin antagonist, is another pharmacological agent used to control post-operative coagulopathy and bleeding in the cardiac surgery patient.
These liposomes, dispersed in 10% serum-containing growth medium, efficiently delivered ON precondensed by protamine sulfate (PS) into HeLa cells.
The heparin drip was discontinued, and protamine sulfate and fresh frozen plasma were administered.
 
 
 
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