protamine


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to protamine: protamine insulin

protamine

 [pro´tah-min]
any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol. Protamines neutralize heparin, and protamine sulfate is used as an antidote in heparin overdosage, administered intravenously.

pro·ta·mine

(prō'tă-mēn, -min),
Any of a class of proteins, highly basic because rich in l-arginine and simpler in constitution than the albumins and globulins, etc., found in fish spermatozoa in combination with nucleic acid; the protamines have a histonelike function and are present in mammalian sperm; neutralizes anticoagulant action of heparin; used in the preparation of several long-acting insulin preparations.

protamine

/pro·ta·mine/ (prōt´ah-min) one of a class of basic proteins occurring in the sperm of certain fish, having the property of neutralizing heparin; the sulfate salt is used as an antidote to heparin overdosage.

protamine

(prō′tə-mēn′, -mĭn) also

protamin

(-mĭn)
n.
Any of a group of arginine-rich proteins that bind to and package DNA in the sperm nucleus. Protamines are used in long-acting formulations of insulin and to neutralize the anticoagulant effects of heparin.

pro·ta·mine

(prō'tă-mēn)
Any of a class of proteins found in fish sperms in combination with nucleic acid; neutralizes anticoagulant action of heparin.

protamine

any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol, found combined with nucleic acids in the sperm of certain fish, and having the property of neutralizing heparin. Protamine sulfate is used as an antidote to heparin overdosage.

protamine paracoagulation
used to examine a blood sample for fibrin monomers and fibrinogen-split products.
protamine zinc insulin (PZI)
see insulin.
References in periodicals archive ?
Protamine overdose and its impact on coagulation, bleeding, and transfusions after cardiopulmonary bypass: results of a randomized double-blind controlled pilot study.
If bleeding is life-threatening, immediate reversal of UFH activity can be achieved by administration of protamine sulphate.
The sperm chromatin condensation was shown with CMA3 assay; indicating protamine defects during his-tone-protamine replacement of sperm chromatin condensation in the testicular phase (21).
Protamine 1: protamine 2 stoichiometry in the sperm of eutherian mammals.
Number Corre- Bias, 95% CI for of lation kU/L bias (a) samples coeffi- cient Protamine sensor:Hepcon 163 0.
Most of these patients receive large doses of protamine to reverse heparin anticoagulation.
NovoLog Mix 70/30 (70% insulin aspart protamine suspension and 30% insulin aspart injection, [rDNA origin]) is a man-made insulin that is used to control high blood sugar in adults with diabetes mellitus.
Weaning from bypass was achieved using the IABP and residual heparin was neutralized with protamine sulphate 3 mg/kg.
The activated clotting time (ACT) is the most commonly used method for monitoring heparin anticoagulation during CPB, based on ease of use and a few early studies that demonstrated a reduction in postoperative bleeding when the ACT was used to monitor heparin and protamine therapy.
4 USP units/mL by protamine titration, and average initial rates of heparin infusion were [greater than or equal to] 30 000 units/24 h [4].
Novo Nordisk offers a comprehensive line of insulin analog products that include Levemir (insulin detemir [rDNA origin] injection), NovoLog [insulin aspart (rDNA origin) injection], and NovoLog Mix 70/30 (70% insulin aspart protamine suspension and 30% insulin aspart injection, [rDNA origin]).
Tenders are invited for Supply of 30 Percent Soluble Insulin As Part Plus 70 Percent Insulin As Part Protamine - 100 Iu X 1 Ml X 3 Ml - Novomix Penfills