protamine


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Related to protamine: protamine insulin

protamine

 [pro´tah-min]
any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol. Protamines neutralize heparin, and protamine sulfate is used as an antidote in heparin overdosage, administered intravenously.

pro·ta·mine

(prō'tă-mēn, -min),
Any of a class of proteins, highly basic because rich in l-arginine and simpler in constitution than the albumins and globulins, etc., found in fish spermatozoa in combination with nucleic acid; the protamines have a histonelike function and are present in mammalian sperm; neutralizes anticoagulant action of heparin; used in the preparation of several long-acting insulin preparations.

protamine

/pro·ta·mine/ (prōt´ah-min) one of a class of basic proteins occurring in the sperm of certain fish, having the property of neutralizing heparin; the sulfate salt is used as an antidote to heparin overdosage.

protamine

(prō′tə-mēn′, -mĭn) also

protamin

(-mĭn)
n.
Any of a group of arginine-rich proteins that bind to and package DNA in the sperm nucleus. Protamines are used in long-acting formulations of insulin and to neutralize the anticoagulant effects of heparin.

pro·ta·mine

(prō'tă-mēn)
Any of a class of proteins found in fish sperms in combination with nucleic acid; neutralizes anticoagulant action of heparin.

protamine

any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol, found combined with nucleic acids in the sperm of certain fish, and having the property of neutralizing heparin. Protamine sulfate is used as an antidote to heparin overdosage.

protamine paracoagulation
used to examine a blood sample for fibrin monomers and fibrinogen-split products.
protamine zinc insulin (PZI)
see insulin.
References in periodicals archive ?
The efficacy and safety of insulin lispro protamine has been investigated in 4 randomized, open-label, parallel-group trials as add-on therapy to oral agents (1 study also included exenatide) over 24 to 36 weeks.
Protamine overdose and its impact on coagulation, bleeding, and transfusions after cardiopulmonary bypass: results of a randomized double-blind controlled pilot study.
Conclusion: Local protamine is more effective in reducing post-operative blood loss than local tranexamic acid.
The sperm chromatin condensation was shown with CMA3 assay; indicating protamine defects during his-tone-protamine replacement of sperm chromatin condensation in the testicular phase (21).
Protamine 1: protamine 2 stoichiometry in the sperm of eutherian mammals.
The presence of additional TATA boxes in the flanking regions of the trout protamine genes as well as the presence of conserved AATAAA poly-adenylation signals.
At the present time, a substance known as protamine sulfate is the only agent in the world that is available commercially to reverse the blood-thinning of heparin.
Humalog Mix[R] 25 (75 percent insulin lispro protamine suspension and 25 percent insulin lispro injection) is a mixture of insulin lispro solution (Humalog[R]), that acts rapidly with insulin lispro protamine suspension, an intermediate acting, blood glucose towering agent.
Type 2 diabetes patients have a greater likelihood of having an acute myocardial infarction if they are treated with insulin glargine than if they are treated with human neutral protamine hagedorn insulin, according to findings from a large retrospective study.