protamine

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protamine

 [pro´tah-min]
any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol. Protamines neutralize heparin, and protamine sulfate is used as an antidote in heparin overdosage, administered intravenously.

pro·ta·mine

(prō'tă-mēn, -min),
Any of a class of proteins, highly basic because rich in l-arginine and simpler in constitution than the albumins and globulins, etc., found in fish spermatozoa in combination with nucleic acid; the protamines have a histonelike function and are present in mammalian sperm; neutralizes anticoagulant action of heparin; used in the preparation of several long-acting insulin preparations.

protamine

/pro·ta·mine/ (prōt´ah-min) one of a class of basic proteins occurring in the sperm of certain fish, having the property of neutralizing heparin; the sulfate salt is used as an antidote to heparin overdosage.

protamine

(prō′tə-mēn′, -mĭn) also

protamin

(-mĭn)
n.
Any of a group of arginine-rich proteins that bind to and package DNA in the sperm nucleus. Protamines are used in long-acting formulations of insulin and to neutralize the anticoagulant effects of heparin.

pro·ta·mine

(prō'tă-mēn)
Any of a class of proteins found in fish sperms in combination with nucleic acid; neutralizes anticoagulant action of heparin.

protamine

any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol, found combined with nucleic acids in the sperm of certain fish, and having the property of neutralizing heparin. Protamine sulfate is used as an antidote to heparin overdosage.

protamine paracoagulation
used to examine a blood sample for fibrin monomers and fibrinogen-split products.
protamine zinc insulin (PZI)
see insulin.
References in periodicals archive ?
gramadigmt Oster-Bu caltsma, protamin lerin ise hic.
Protamin sonrasi yapilan heparinazli TEG olcumlerinde uzamis R zamani Heparin artik etkisini gosterir ve ek doz protamin ile duzeltilmelidir.
5 Mg Of Insulin Aspart R-Dna Origin 30 Percentage As Soluble Insulin Aspart And 70 Percentage As Insulin Aspart Protamin Crystal.
It is then that changes in nuclear protein composition occur as a result of which histones are replaced with protamins.
Following fertilization and oocyte activation, however, the paternal genome is remodeled after replacement of its protamins with histones from the oocyte, and re-acetylation gradually initiates in the zygotic pronuclei (Spinaci et al.