KLK15

(redirected from prostinogen ACO protease)

KLK15

A gene on chromosome 19q13.3-q13.4 that encodes a serine  endopeptidase with a trypsin- and chymotrypsin-like substrate specificity, which may: activate/inactivate proteinase-activated receptors F2R, F2RL1 and F2RL3, as well as other kallikreins (e.g., KLK1, KLK3, KLK5 and KLK11); liquefy seminal clot by cleaving semenogelins SEMG1 and SEMG2 and activating KLK3; cleave desmoglein DSG1, resulting in shedding of superficial keratinocytes from the skin surface; and play a role in tumour progression by affecting growth, invasion and angiogenesis.