prostatic intraepithelial neoplasia


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pros·tat·ic in·tra·ep·i·the·li·al ne·o·pla·si·a (PIN),

dysplastic changes involving glands and ducts of the prostate that may be a precursor of adenocarcinoma; low grade (PIN 1), mild dysplasia with cell crowding, variation in nuclear size and shape, and irregular cell spacing; high grade (PIN 2 and 3), moderate to severe dysplasia with cell crowding, nucleomegaly and nucleolomegaly, and irregular cell spacing.

pros·tat·ic in·tra·ep·i·the·li·al ne·o·pla·si·a

(PIN) (pros-tat'ik in-tra-ep'i-thē'lē-ăl nē'ō-plā'zē-ă)
Dysplastic changes involving glands and ducts of the prostate that may be a precursor of adenocarcinoma; low grade (PIN 1), mild dysplasia with variation in nuclear size and shape and irregular cell spacing; high grade (PIN 2 and 3), moderate to severe dysplasia with nucleomegaly, nucleolomegaly, and irregular cell spacing.
References in periodicals archive ?
Multifocal high grade prostatic intraepithelial neoplasia is a significant risk factor for prostatic adenocarcinoma.
Two critical histological diagnoses that are predictive of an underlying prostatic adenocarcinoma are atypical small acinar proliferations (ASAP), also referred to as ATYP, and high-grade prostatic intraepithelial neoplasia (HGPIN).
1 = screening/early detection; no known prostate cancer or prostatic intraepithelial neoplasia (PIN); 2 = screening/early detection; history of high grade PIN, no known prostate cancer; 3 = active surveillance (no treatment); known prostate cancer; 4 = hormonal therapy, chemotherapy, or post-orchiectomy; 5 = post-radical prostatectomy; 6 = post-external beam radiation; 7 = post-brachytherapy; 8 = post-high intensity focused ultrasound.
High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases.
This study included 23 men (average age 64 years) with high-grade prostatic intraepithelial neoplasia, a precursor to prostate cancer.
GTx is conducting a separate pivotal Phase III clinical trial evaluating ACAPODENE 20 mg for the prevention of prostate cancer in men with high grade prostatic intraepithelial neoplasia (PIN).
An extract of the catechins found in green tea appears to be effective in preventing the progression of high-grade prostatic intraepithelial neoplasia to invasive prostate cancer, Saverio Bettuzzi, Ph.
Nasdaq: GTXI) today announced the expansion of their partnership for the development and commercialization of toremifene 80 mg for the reduction of fractures in men with advanced prostate cancer on androgen deprivation therapy (ADT) and toremifene 20 mg for the prevention of prostate cancer in high risk patients with High Grade Prostatic Intraepithelial Neoplasia lesions (HGPIN).
2) [alpha]-Methylacyl-coenzyme A racemase also stains almost all high-grade prostatic intraepithelial neoplasia (HGPIN), (2-4) the presumed precursor lesion of PCa, limiting its utility for molecular stratification of subsequent cancer risk.
Negative prostatic biopsy with rising PSA levels or the presence of suspicious prostatic lesions, high-grade prostatic intraepithelial neoplasia (HGPIN) or atypical small acinar proliferation (ASAP) are challenging dilemmas facing urologists.
Investigators recruited 22 men, 55-70 years old, with a pre-existing diagnosis of high-grade prostatic intraepithelial neoplasia (PIN), the pre-invasive stage of prostate cancer.