It modulates the expression of proinflammatory genes transcription for cytokines, growth factors, adhesion molecules, nitric oxide, prostanoids
Based on the known mechanisms, 3 classes of drugs have been used to treat pediatric pulmonary hypertension (PH): prostanoids
are cyclic and oxygenated metabolites comprised of [omega]-3 and [omega]-6 20-carbon essential fatty acids, and they have a broad range of biological activities.
Their primary influence is on the cyclooxygenase or COX pathway, in which chemical reactions create prostanoids
, a family of lipid mediators that cause pain and inflammation in nerve endings and in the spinal cord.
The body's inflammatory response involves an enzyme, cyclooxygenase (COX), that helps form prostanoids
, key components in the development of inflammation.
Sodium tungstate and vanadyl sulfate effects on blood pressure and vascular prostanoids
production in fructose-overloaded rats.
COX enzyme metabolizes arachidonic acid to the prostanoids
2+]/NFAT cascade in cardiomyocytes, leading to cyclooxygenase type 2 (COX-2) induction and increased release of prostanoids
and prohypertrophic peptides.
The method has been associated with prostanoids
in general, e.
A disruption in immune tolerance, results in excitement that may involve multiple pathways such as production of cytotoxic antibodies, activation of T-cells (Feghali and Wright, 1997; Barton, 1999) cytokines and prostanoids
(prostaglandins, prostacyclin, and thromboxane) production from arachidonic acid during chronic inflammation.
In addition, cytokines and prostanoids
, as well as matrix metalloproteinases activated through the host response, may stimulate damage to connective tissue and bone and shape the clinical presentation of disease.
Cyclooxygenase- (COX-) 1 and COX-2 are the two isoforms of cyclooxygenase, both of which catalyze the transformation of arachidonic acid to prostanoids