prostaglandin endoperoxide synthase


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prostaglandin endoperoxide synthase

 [pros″tah-glan´din en″do-per-ok´sīd sin´thās]
an enzyme of the oxidoreductase class that has both cyclooxygenase and peroxidase activities, which together catalyze part of the synthesis of prostaglandins and thromboxanes from arachidonic acid.

pros·ta·glan·din en·do·per·ox·ide syn·thase

a protein complex that catalyzes two steps in prostaglandin biosynthesis; the cyclooxygenase activity (which is inhibited by aspirin and indomethacin) converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.
Synonym(s): cyclooxygenase

prostaglandin endoperoxide synthase

[pros′tah·glan′din en′doperok′sīd sin′thās]
an enzyme of the oxidoreductase class that has both cyclooxygenase and peroxidase activities, which together catalyze part of the synthesis of prostaglandins and thromboxanes from arachidonic acid.
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