Supplies of timolol (Timoptol), dorzolamide (Trusopt) and dorzolamide with timolol (Cosopt) preservative-free products were affected but MSD's preservative-free prostaglandin analogue tafluprost (Saflutan) was not, owing to a different source of manufacture (Santen Pharmaceutical).
Later that year Alcon changed the formulation of their prostaglandin analogue, travoprost (Travatan) and in early 2011 that of travoprost with timolol (Duotrav) replacing the preservative benzalkonium chloride with Polyquad.
WHO Task Force On Post-Ovulatory Methods For Fertility Regulation, Termination Of Early Human Pregnancy With RU 486 (Mifepristone) And The Prostaglandin Analogue Sulprostone: A Multi-Centre, Randomized Cemparison Between Two Treatment Regimens, 4 Hum.
1989, at 27 (1989); Rodger & Baird, Blood Loss Following Induction Of Early Abortion Using Mifepristone (RU 486) And A Prostaglandin Analogue (Gemeprost), 40 Contraception 439 (1989) (hereafter "Rodger & Baird, 1989"); Cameron, et al.
Pre-operative risk factors include active or history of uveitis, diabetes, previous retinal vein occlusion, AMD, epiretinal membrane (ERM), vitreo-macular traction (VMT), previous CMO, and use of prostaglandin analogues for glaucoma treatment.
Table 1 Risk factors for PCMO Risk factors for PCMO Intra-operative Pre-operative Vitreous loss History of uveitis Vitreous traction at incision site Epiretinal membrane Vitrectomy for retained lens Vitreo-macular traction fragments Iris trauma Previous CMO Posterior capsule rupture Use of prostaglandin analogues IOL dislocation Diabetes Early post-operative capsulotomy History of retinal vein occlusion Iris fixated or anterior chamber AMD IOL
However, prostaglandin analogues
are usually avoided as they may serve to augment the inflammatory response.
As a very rough rule of thumb, the favoured first and second line treatments are beta-blockers or prostaglandin analogues
, unless contraindicated.
The approval sets the stage for marketing authorization of DuoTrav(TM) eye drops solution in the European Union (EU) to decrease IOP in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to topical beta-blockers or prostaglandin analogues
Travatan(R) ophthalmic solution is a glaucoma medication from Alcon that has proven to be more effective in lowering intraocular pressure than other prostaglandin analogues
The two most widely prescribed classes of glaucoma medications are prostaglandin analogues
The two most widely prescribed classes of glaucoma medications today are prostaglandin analogues