alprostadil

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alprostadil

 [al-pros´tah-dil]
name for prostaglandin E1 when used pharmaceutically as a vasodilator and platelet aggregation inhibitor; used for treatment of patent ductus arteriosus and for diagnosis and treatment of impotence.

al·pros·ta·dil

(al-pros'tă-dil),
A vasodilator used for palliative therapy to maintain patency of the ductus arteriosus in neonates with congenital heart defects temporarily.
Synonym(s): prostaglandin E1

alprostadil

/al·pros·ta·dil/ (al-pros´tah-dil) name for prostaglandin E when used pharmaceutically as a vasodilator and platelet aggregation inhibitor; used for the treatment of patent ductus arteriosus and the diagnosis and treatment of impotence.

alprostadil

(ăl-prŏs′tə-dĭl)
n.
A prostaglandin drug, C20H34O5, that acts as a vasodilator and is used in suppository or injectable form to treat erectile dysfunction.

alprostadil

a proprietary form of prostaglandin E1 used to treat impotence and (temporarily) to maintain the patency of the ductus arteriosus in certain neonates.
indication It is recommended as palliative therapy for neonates awaiting surgery to correct congenital cardiac anomalies, such as tetralogy of Fallot and tricuspid atresia.
contraindications It is contraindicated in respiratory distress syndrome and in cases of known hypersensitivity. This drug is contraindicated in pregnant patients.
adverse effects The most common adverse effects are apnea, fever, seizures, cerebral bleeding, flushing, bradycardia, and hypertension.

alprostadil

Urology A formulation of PGE-1 which relaxes the corpus cavernosum, allowing engorging during erection. See Erectile dysfunction, Orgasm.

alprostadil

A PROSTAGLANDIN drug used by penile injection for the treatment of impotence. An erection lasting for two or three hours is commonly achieved, but sales of alprostadil may be adversely affected by the development of drugs such as VIAGRA. Brand names are Caverject, Muse, and Viridal Duo.

Alprostadil

A smooth muscle relaxant sometimes injected into the penis or applied to the urethral opening to treat impotence.
Mentioned in: Impotence

al·pros·ta·dil

(al-pros'tă-dil)
A vasodilator used for palliative therapy to maintain patency of the ductus arteriosus in neonates with congenital heart defects temporarily.
Synonym(s): prostaglandin E1.

alprostadil (alpros´tədil´),

n brand name: Caverject;
drug class: naturally occurring prostaglandin;
action: induces erection by relaxation of trabecular smooth muscle and by dilation of cavernosal arteries;
uses: treatment of erectile dysfunction caused by neurogenic, vasculogenic, psychogenetic, or mixed etiology.
References in periodicals archive ?
Misoprostol, a prostaglandin E1 analogue was used in obstetrics because of its uterotonic and cervical ripening effects in different studies (7, 10).
President and Chief Executive Officer of NexMed, stated, "Given the disease characteristics, Raynaud's syndrome is an appealing product opportunity for us and one that we believe can benefit strongly from the active ingredient in Vitaros, which is alprostadil, or prostaglandin E1 (PGE1), a potent vasodilator.
Research indicates that DGLA's benefits for hyper-proliferative skin disorders may be due to the fatty acid's role as the raw material in the creation of potent anti-inflammatory compounds called prostaglandin E1 and 15-HETrE.
Researchers at the Stanford University School of Medicine are looking for volunteers to participate in a multicenter clinical study on the effectiveness of a topical solution containing alprostadil, or prostaglandin E1, in treating the sexual disorder in hysterectomy patients.
Endovasc recently announced its intention to create a new subsidiary to showcase its promising ProStent technology with is a patented stent coating comprised of a polymer and prostaglandin E1 (PGE1).
Endovasc recently announced its intention to create a new subsidiary to showcase its promising ProStent technology with a patented stent coating comprised of a polymer and prostaglandin E1 (PGE1).
The estimated 5-6 million patients who do not respond or cease to respond to PDE inhibitors are candidates for treatment with injectable prostaglandin E1 (PGE1; also known as alprostadil) sterile power for injection products such as CAVERJECT(TM) (Pfizer/Pharmacia) and EDEX(TM) (Schwarz Pharma) or other more invasive means.
MacroChem is developing three products containing its patented drug-absorption enhancer, SEPA(R): Topiglan(R), a SEPA-enhanced synthetic prostaglandin E1, for erectile dysfunction; Opterone(TM), a SEPA-enhanced topical treatment for men with testosterone deficiency; and EcoNail(TM), a SEPA-enhanced antifungal nail lacquer to treat a common and potentially debilitating nail infection known as onychomycosis.
ProStent is Endovasc's patented stent coating comprised of a polymer and prostaglandin E1 (PGE1).
ALISTA's active ingredient, alprostadil, is a synthetic version of prostaglandin E1 (PGE1), a naturally occurring vasodilating agent.
In addition to Opterone, MacroChem is developing two other products containing its patented drug-absorption enhancer, SEPA(R): Topiglan(R), a SEPA-enhanced synthetic prostaglandin E1, for erectile dysfunction; and EcoNail(TM), a SEPA- enhanced antifungal nail lacquer to treat a common and potentially debilitating nail infection known as onychomycosis.
In addition to Opterone, MacroChem is developing two other products containing its patented drug-absorption enhancer, SEPA(R): Topiglan(R), a SEPA- enhanced synthetic prostaglandin E1, for erectile dysfunction; and EcoNail (TM), a SEPA-enhanced antifungal nail lacquer to treat a common and potentially debilitating nail infection known as onychomycosis.