prostacyclin


Also found in: Dictionary, Acronyms, Wikipedia.

prostacyclin

 [pros″tah-si´klin]
a prostaglandin, PGI2, synthesized by endothelial cells lining the walls of arteries and veins; it is a potent vasodilator and a potent inhibitor of platelet aggregation. When used pharmaceutically it is called epoprostenol.

pros·ta·cy·clin

(pros'tă-sī'klin),
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.

prostacyclin

/pros·ta·cy·clin/ (pros″tah-si´klin) a prostaglandin, PGI2, synthesized by endothelial cells lining the cardiovascular system; it is a potent vasodilator and inhibitor of platelet aggregation. It is used pharmaceutically as epoprostenol.

prostacyclin

(prŏs′tə-sī′klĭn)
n.
A prostaglandin produced in the walls of blood vessels that acts as a vasodilator and inhibits platelet aggregation.

prostacyclin (PGI2)

[pros′təsī′klin]
a prostaglandin. It is a biologically active product of arachidonic acid metabolism in human vascular walls and a potent inhibitor of platelet aggregation. It inhibits the vasoconstrictor effect of angiotensin and stimulates renin release and has been used to treat pulmonary hypertension.

pros·ta·cy·clin

(pros'tă-sī'klin)
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.

prostacyclin

A short-acting hormone produced by the lining of blood vessels (ENDOTHELIUM) and by the lungs, that limits the aggregation of PLATELETS and is probably of major importance in preventing THROMBOSIS. Prostacyclin has a half-life of only 2–3 minutes.

prostacyclin

powerful vasoconstrictor, released by vascular endothelium

pros·ta·cy·clin

(pros'tă-sī'klin)
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.

prostacyclin

a metabolite of arachidonic acid formed by prostaglandin endoperoxides in the walls of arteries and veins; it is a potent vasodilator and an inhibitor of platelet aggregation. The exogenous form is called epoprostenol.
References in periodicals archive ?
Improved cerebral oxygenation after high-dose inhaled aerosolized prostacyclin therapy for acute lung injury: A case report.
These studies have indicated that in addition to and independently from their antioxidant effects, polyphenols enhance the productions of vasodilating factors; NO, endothelium-derived factor (EDHF), together with prostacyclin and inhibit the synthesis of vasocontrictor endothelin-1 in endothelial cells.
Prostacyclin is a potent vasodilator, platelet inhibitor and antimitogen.
In the lungs, NO is produced by NO synthases located in the vascular endothelium and airway epithelium, where it exerts a vasodilatory effect alongside prostacyclin and other endogenous vasodilators.
Remodulin is better as a treatment than giving the natural prostacyclin because it works longer and is more stable.
The Phase IV study involves a randomized transition of patients treated with Flolan, a synthetic form of prostacyclin that is delivered intravenously, to either subcutaneous Remodulin or to placebo.
These include prostaglandin analogs such as prostacyclin and low-dose inhaled nitric oxide.
3) Another agent, the prostacyclin analog iloprost, has potent vasodilatory and antiplatelet effects.
Women who have preeclampsia, a dangerous pregnancy complication marked by high blood pressure, also have unusually low concentrations of a fatty acid derivative called prostacyclin, a new study shows.
The loss of this source of prostacyclin could help explain why women who have had hysterectomies are prone to cardiovascular problems.
They selected this treatment because it increases release of beneficial substances, such as nitric oxide, prostacyclin, prostaglandin E2, and adrenomedullin, from the inner lining of blood vessels into the circulation.