prostacyclin


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prostacyclin

 [pros″tah-si´klin]
a prostaglandin, PGI2, synthesized by endothelial cells lining the walls of arteries and veins; it is a potent vasodilator and a potent inhibitor of platelet aggregation. When used pharmaceutically it is called epoprostenol.

pros·ta·cy·clin

(pros'tă-sī'klin),
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.

prostacyclin

/pros·ta·cy·clin/ (pros″tah-si´klin) a prostaglandin, PGI2, synthesized by endothelial cells lining the cardiovascular system; it is a potent vasodilator and inhibitor of platelet aggregation. It is used pharmaceutically as epoprostenol.

prostacyclin

(prŏs′tə-sī′klĭn)
n.
A prostaglandin produced in the walls of blood vessels that acts as a vasodilator and inhibits platelet aggregation.

prostacyclin (PGI2)

[pros′təsī′klin]
a prostaglandin. It is a biologically active product of arachidonic acid metabolism in human vascular walls and a potent inhibitor of platelet aggregation. It inhibits the vasoconstrictor effect of angiotensin and stimulates renin release and has been used to treat pulmonary hypertension.

pros·ta·cy·clin

(pros'tă-sī'klin)
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.

prostacyclin

A short-acting hormone produced by the lining of blood vessels (ENDOTHELIUM) and by the lungs, that limits the aggregation of PLATELETS and is probably of major importance in preventing THROMBOSIS. Prostacyclin has a half-life of only 2–3 minutes.

prostacyclin

powerful vasoconstrictor, released by vascular endothelium

pros·ta·cy·clin

(pros'tă-sī'klin)
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.

prostacyclin

a metabolite of arachidonic acid formed by prostaglandin endoperoxides in the walls of arteries and veins; it is a potent vasodilator and an inhibitor of platelet aggregation. The exogenous form is called epoprostenol.
References in periodicals archive ?
1989) On the mechan ism of prostacyclin and thromboxane [A.
Tanabe, Over expression of prostacyclin synthase inhibits growth of vascular smooth muscle cells, Biochemical and Biophysical Research Communication, 216(3), 862-867 (1995).
COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice.
Treprostinil (Remodulin[R]) is a stable form of synthetic prostacyclin with a half-life of several hours.
The unexpected finding of the vasodilator prostacyclin while we were looking for the vasoconstrictor thromboxane [A.
Hypoxia-reoxygenation triggers coronary vasospasm in isolated bovine coronary arteries via tyrosine nitration of prostacyclin synthase.
Infusion of prostacyclin following experimental brain injury in the rat reduces cortical lesion volume.
Inhaled aerosolized prostacyclin as a selective pulmonary vasodilator for the treatment of severe hypoxaemia.
Binding of insulin to platelets increases the number and activity of adenylatecyclase-linked prostacyclin receptors on their surface.
And the trans fats and cigarette smoke interfere with the production of a compound, prostacyclin, which normally keeps the blood fluid.
Atrial natriuretic peptide-induced changes in renal prostacyclin production in ureteral obstruction.
Additionally, the data exist that garlic, unlike aspirin, does not affect the prostacyclin synthesis in vascular wall, thus sustaining antithrombogenic properties of endothelial cells (Ali and Mohammed, 1986; Srivastava, 1986).