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prostacyclin

   Also found in: Dictionary/thesaurus, Acronyms, Wikipedia, Hutchinson 0.01 sec.
prostacyclin /pros·ta·cy·clin/ (pros″tah-si´klin) a prostaglandin, PGI2, synthesized by endothelial cells lining the cardiovascular system; it is a potent vasodilator and inhibitor of platelet aggregation. It is used pharmaceutically as epoprostenol.
pros·ta·cy·clin (prst-skln)
n.
A prostaglandin produced in the walls of blood vessels that acts as a vasodilator and inhibits platelet aggregation.

prostacyclin (PGI2)
[pros′təsī′klin]
a prostaglandin. It is a biologically active product of arachidonic acid metabolism in human vascular walls and a potent inhibitor of platelet aggregation. It inhibits the vasoconstrictor effect of angiotensin and stimulates renin release and has been used to treat pulmonary hypertension.

prostacyclin [pros″tah-si´klin]
a prostaglandin, PGI2, synthesized by endothelial cells lining the walls of arteries and veins; it is a potent vasodilator and a potent inhibitor of platelet aggregation. When used pharmaceutically it is called epoprostenol.

prostacyclin
a metabolite of arachidonic acid formed by prostaglandin endoperoxides in the walls of arteries and veins; it is a potent vasodilator and an inhibitor of platelet aggregation. The exogenous form is called epoprostenol.


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Our increased stock price also highlights our mature pipeline, which has the potential for further growth through continued market penetration by Remodulin, our recent launch of Adcirca, the only once-daily PDE-5 inhibitor for PAH, and the expected launch of Tyvaso, our now FDA-approved inhaled prostacyclin analogue.
Trans fats also were shown to interfere with an enzyme that converts the essential fatty acid linoleic acid into arachidonic acid, which is needed for the production of prostacyclin (a blood-flow enhancer) and thromboxane (which regulates the formation of blood clots needed for wound healing).
It is interesting to note that recent studies have found that CNP complements nitric oxide (NO) and prostacyclin, which are also mediators of vasodilation.
 
 
 
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