prorenin

prorenin

 [pro-ren´in]
the inactive precursor of renin, stored in the juxtaglomerular cells of the kidney and activated by cleavage to renin. Called also big renin.

prorenin

[prōren′in]
the inactive precursor of renin, stored in the juxtaglomerular cells of the kidney and activated by cleavage to renin. Also called big renin.
References in periodicals archive ?
I am very appreciative to our entire R&D team for developing this unique ELISA kit which for the first time allows for both the rapid and quantitative measurement of human prorenin.
3 Prorenin is synthesized and stored in vesicles until cellular signaling results in release of bioactive renin into plasma.
Award for services of Medicinal Chemistry (MC) in a preclinical pharmacological Medikamentenentwicklungzur optimization of antagonists of the renin / prorenin receptor (RER) signaling pathway forthe Charite - UniversitEntsmedizin Berlin.
Clinical validation of renin monoclonal antibodybased sandwich assays of renin and prorenin, and use of renin inhibitor to enhance prorenin immunoreactivity.
1998) Determinants of interindividual variation of renin and prorenin concentrations: evidence for a sexual dimorphism of (pro) renin levels in humans.
Yuksek duzeylerde prorenin ve angiotensin II, follikul sivi icerisinde saptanmis ve OHSS'lu hastalarin plazma renin seviyeleri yuksek bulunmustur [6].
The real interest in aliskiren will be the insight it provides into "the relationship between prorenin [the biosynthetic precursor of renin] and renin, and its role in modulating the renin angiotensin aldosterone system," he commented in an interview.
Now, a study suggests that a diabetic's prorenin levels may increase significantly 18 months before any vessel damage shows up in the eyes or kidneys.
In vitro conversion of prorenin to renin can occur via cryoactivation when samples are stored at temperatures between --5[degrees]C and 4[degrees]C (7-9).
The first reports of inactive renin or prorenin in plasma were published at that time (3).
On the other hand, the specificity of the IRMA method has been questioned because the inactive precursor of renin, prorenin, may be converted on prolonged incubation at room temperature into a renin-like conformation that leads to comeasurement of prorenin as renin (2, 3).
The first monoclonal antibody is biotin-labeled and is used to capture renin by recognizing both active renin and prorenin.