proprotein

proprotein

 [pro-pro´tēn]
a protein precursor that is cleaved to form an active protein, e.g., proinsulin, the precursor of insulin.

proprotein

/pro·pro·tein/ (pro-pro´tēn) a protein that is cleaved to form a smaller protein, e.g., proinsulin, the precursor of insulin.

proprotein

a protein which is cleaved to form a smaller protein, e.g. proinsulin, the precursor of insulin.
References in periodicals archive ?
Of these segments, anti-hypertensives and cholesterol-lowering drugs are emerging as the most promising therapy class owing to the development of drugs targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) and cholesteryl ester transfer protein (CETP).
Proteins that enter the secretory pathway are initially synthetized as biologically inactive precursors requiring proteolytic cleavage by highly specialized and evolutionarily conserved proprotein convertases.
Furin is a ubiquitous proprotein convertase enriched in the trans-Golgi network and is well-conserved among mammals (20).
Combinatorial Environmental Stress and Subtilisin-like Proprotein Convertase Expression.
Persons with genetically lifelong low LDL-C levels--resulting from hypobetalipoproteinaemia or loss-of-function mutations in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene--have a markedly reduced risk (80-90%) of developing CAD, despite a similar prevalence of other CVD risk factors.
Among the other 15 papers in these proceedings are discussions of extragastrointestinal functions and the transcriptional regulation of secretin and secretin receptors, PACAP as a master regulator of neuroendocrine stress circuits and the cellular stress response, the development of the zebrafish hypothalamus, the behavioral effect of neuropeptides related to feeding regulation in fish, and what lies ahead for the proprotein convertases.
Recently, a third gene, proprotein convertase subtilisin/ kexin type 9 (PCSK9), causing autosomal dominant hypercholesterolemia Type 3 (OMIN 603776) has been described.
PCSK9 proprotein convertase promotes the degradation of the receptor responsible for eliminating LDL-cholesterol particles.
In the budding yeast Saccharomyces cerevisiae, Kex2p is a membrane-bound proprotein processing protease (PPP) required for proper mating function.
The program, in collaboration with University of Texas (UT) Southwestern Medical Center at Dallas, is focused on evaluating new approaches for reducing LDL cholesterol levels using RNAi therapeutics directed to the disease target called proprotein convertase subtilisn/kexin type 9, or PCSK9.
ALN-PCS is a systemically delivered RNAi therapeutic targeting the gene proprotein convertase subtilisin/kexin type 9 (PCSK9), a target validated by human genetics that is involved in the metabolism of low-density lipoprotein cholesterol (LDL-C, or "bad" cholesterol).