propositus


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.

pro·pos·i·tus

, pl.

pro·po·si·ti

(prō-poz'i-tŭs, -tī),
1. Proband, usually referring to the first index case to be ascertained. Compare: consultand.
2. A premise; an argument.
[L. fr. propono, pp. -positus, to lay out, propound]

propositus

/pro·pos·i·tus/ (pro-poz´ĭ-tus) pl. propo´siti   [L.] proband; often specifically the first proband to be ascertained.

propositus

(prō-pŏz′ĭ-təs)
n. pl. proposi·ti (-tī′)
1. Law The person who is the subject of a question or action.
2. A person to whom descendants are commonly related.

propositus

[prōpoz′itəs]
Etymology: L, proponere, to place forward
a person from whom a genealogical lineage is traced, as is done to discover the pattern of inheritance of a familial disease or a physical trait. Also called proband.

pro·pos·i·tus

, pl. propositi (prō-poz'i-tŭs, -tī)
1. Proband distinguished by sex.
2. A premise; an argument.
[L. fr. propono, pp. -positus, to lay out, propound]

pro·pos·i·tus

, pl. propositi (prō-poz'i-tŭs, -tī)
1. Proband, usually referring to the first index case to be ascertained.
2. A premise; an argument.
[L. fr. propono, pp. -positus, to lay out, propound]

propositus

pl. propositi [L.] the original animal presenting a disease or disorder which serves as the basis for a hereditary or genetic study; called also proband.
References in periodicals archive ?
Whole blood (20 mL) was collected from the propositus in a tube containing heparin and mixed with 13 mL of a solution containing 20 g/L dextran and 0.
0 [micro]g of RNA from the propositus and oligo[(dT).
The sequence of CD13 cDNA from the propositus (nucleotides 94-3374), including the entire translated region (nucleotides 121-3024), was identical to the sequence reported previously (4) with minor exceptions: nucleotide residue 228, previously reported as G, was found to be either G or A; nucleotides 231 and 237, previously reported as Gs, were either G or A; and nucleotide 372, previously reported as C, was either C or T.
Hence, no explanation for the extremely low oxygen affinity of whole blood observed in the propositus is evident from the hematological and structural data.
The FVII-TF binding in the propositus was lower than in healthy controls.
Propositus Father Mother Sister FVII:C, (a) % Rabbit brain TF 6 38 72 44 Recombinant human TF 38 95 69 95 Human placenta TF 36 90 68 80 Bovine brain TF 68 110 100 120 Simian brain TF 35 65 69 65 FVII: ag, (b) % ELISA-1 5 32 72 34 ELISA-2 63 95 75 100 ELISA-3 65 100 77 105 QIEP 64 100 78 110 (a) FVII:c was measured by a one-stage method using FVII-depleted plasma as a substrate and various TFs: rabbit brain TF (CRB thromboplastin, Roche Diagnostica), recombinant human TF (Innovin, Baxter Diagnostics), human placenta TF (Thromborel S, Behringwerke), bovine brain TF (kindly provided by Dr.
Because a serum sample of the propositus diluted at 1:5 with PBS showed 449 U/L of LAP activity, which was within the measuring range (<700 U/L), we determined her serum LAP activity as 2245 U/L, 31 times higher than the normal upper limit (73 U/L).
3 in sera with unusually high LAP activities from the propositus, her father, and her grandmother.
Immunoprecipitation of serum from the propositus also showed a single band at the slightly larger position than normal, although the difference was subtle in this assay condition.
The musculoskeletal malformations found in the propositus are diagnostic for this syndrome.
Most likely, the propositus had an ALT deficiency due to absence of active enzyme molecules.
The isolated finding of ALT deficiency in the propositus suggests that both parents must have been heterozygous for ALT deficiency and therefore points towards an autosomal recessive inheritance.