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propositus

   Also found in: Dictionary/thesaurus, Legal, Encyclopedia 0.01 sec.
propositus /pro·pos·i·tus/ (pro-poz´ĭ-tus) pl. propo´siti   [L.] proband; often specifically the first proband to be ascertained.
pro·pos·i·tus (pr-pz-ts)
n. pl. pro·pos·i·ti (-t)
1. See proband.
2. A premise; an argument.

propositus
[prōpoz′itəs]
Etymology: L, proponere, to place forward
a person from whom a genealogic lineage is traced, as is done to discover the pattern of inheritance of a familial disease or a physical trait. Also called proband.

propositus
pl. propositi [L.] the original animal presenting a disease or disorder which serves as the basis for a hereditary or genetic study; called also proband.


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Part of exon h of the F9 gene (Xg27) and part of exon 1 (used as reference) of the [beta]-globin gene (11p15) were amplified by real-time PCR from DNA obtained from the propositus, the two related female patients, unaffected males (n = 5), and female noncarriers (n = 6).
The son of propositus 1 had a 20-year history of Crohn's disease with resection of 2 feet of terminal ileum.
 
 
 
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