propafenone


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propafenone

 [pro″pah-fe´nōn]
a sodium channel blocking agent that acts on the Purkinje fibers and the myocardium; used as the hydrochloride salt in treatment of life-threatening arrhythmias, administered orally.

propafenone

/pro·pa·fe·none/ (pro″pah-fe´nōn) a sodium channel blocking agent acting on the Purkinje fibers and the myocardium; used as the hydrochloride salt as an antiarrhythmic.

propafenone

Rythmol® Cardiology A beta-blocking antiarrhythmic for severe ventricular and supraventricular arrhythmias–A Fib, V Tach, conduction block, HTN Complications Ventricular proarrhythmia; conduction defects Adverse effects Neurologic–headache, dizziness, paresthesias, peripheral neuropathy, GI–eg, N&V, anorexia. See Antiarrhythmic, Beta-blockers.

propafenone

A drug used to treat heart irregularities (arrhythmias). A brand name is Arythmol.

propafenone (prō´pəfē´nōn),

n brand name: Rythmol;
drug class: antidysrhythmic (Class IC);
action: able to slow conduction velocity; reduces cardiac muscle membrane responsiveness; inhibits automaticity; increases ratio of effective refractory period to action potential duration; β-blocking activity;
use: documented life-threatening dysrhythmias.
References in periodicals archive ?
Anti-arrhythmic drugs, such as digoxin, beta-blockers, calcium channel blockers, amiodarone, flecainide and propafenone.
NASDAQ: CRME) (TSX: COM) today announced that the abstract, Conversion of Acute Atrial Fibrillation with Propafenone or Vernakalant, is being presented as an oral presentation by Dr.
Other drugs that Can cause similar and clinically important interactions with warfarin are amiodarone, propafenone, and three antifungals that can be a problem at high doses but not with single doses--ketoconazole/fluconazole, itraconazole, or metronidazole.
Other examples include CYP2C9 genotyping for avoidance of warfarin-related haemorrhage and CYP2D6 genotyping for optimisation of propafenone dosage.
On January 3, 2011, Par Pharmaceutical successfully launched the 225mg, 325mg, and 425mg strengths of propafenone SR capsules, the generic version of GlaxoSmithKline's Rythmol SR [R] .
Propafenone, like other antiarrythmic agents in its class, has caused new or worsened arrythmias and should generally be avoided in patients with structural heart disease and/or non-life-threatening ventricular arrythmias.
Siddoway, LA, Thompson, KA, McAllister, CB, Wang, T, Wilkinson, GR, Roden, DM, Woosley, RL: Polymorphism of propafenone metabolism and disposition in man: Clinical and pharmacokinetic consequences.
All nine of the heart medications studied (labetalol HCI, captopril, diltiazem HCI, enalapril maleate, hydrochlorothiazide, propranolol HCI, mexiletine HCI, procainamide HCI, and propafenone HCI) were described as being predominantly bitter, with other negative qualities including metallic, medicinal, sour, sharp, and astringent.
Rythmol SR, propafenone, anti-arrhythmics, rapid heartbeats, atrial arrhythmias, ventricular arrhythmias, short-life
ANI's first half 2015 results yielded material increases in revenue, EBITDA, operating income, and earnings per share over the prior year period, due primarily to our acquisitions of Lithobid and Vancocin as well as the launch of Methazolamide tablets, Etodolac capsules and Propafenone tablets, three of the generic products we acquired in 2014.