proopiomelanocortin


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pro·o·pi·o·mel·a·no·cor·tin (POMC),

(prō-ō'pē-ō-mel'ă-nō-kōr'tin), [MIM*176830]
A large molecule found in the anterior and intermediate lobes of the pituitary gland, the hypothalamus, and other parts of the brain as well as in the lungs, gastrointestinal tract, and placenta; the precursor of ACTH, CLIP, β-LPH, γ-MSH, β-endorphin, and met-enkephalin.

POMC

A gene on chromosome 2p23 that encodes proopiomelanocortin, the melanocortin family of hormones, which include alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins bind to the melanocortin receptors, a group of five G protein-coupled receptors (MC1R to MC5R) which are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

Molecular pathology
Defects of POMC are associated with susceptibility to obesity and proopiomelanocortin deficiency.

pro·o·pi·o·mel·a·no·cor·tin

(POMC) (prō-ō'pē-ō-mel'ă-nō-kōr'tin)
A large molecule found in the anterior and intermediate lobes of the pituitary gland, the hypothalamus, and other parts of the brain as well as in the lungs, gastrointestinal tract, and placenta.

proopiomelanocortin (POMC)

The prohormone from which ACTH, beta-lipotropin, and beta-ENDORPHIN are produced by cleavage. POMC is found most abundantly in the pituitary and hypothalamus, but also occurs in the sex glands and elsewhere.
References in periodicals archive ?
NF-kappaB participates in the corticotropin-releasing, hormone-induced regulation of the pituitary proopiomelanocortin gene.
Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome.
Several melanocyte-stimulating hormones are normally produced along with ACTH via cleavage of the common precursor protein, proopiomelanocortin.
The melanocortins (melanocyte-stimulating hormones, MSHs) are peptides that derive from proopiomelanocortin (POMC).
Effects of chronic nicotine treatment and withdrawal on hypothalamic proopiomelanocortin gene expression and neuroendocrine regulation.
Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B.
Proopiomelanocortin and the immune-neuroendocrine connection.
saltmalar: POMC: Proopiomelanocortin, VIP: Vazoaktive Intestinal Peptide, CGRP: Calcitonin-Gene Related Peptide, IL: Interleukin
Proopiomelanocortin (POMC) disregulation and response to opiate blockers.
Impaired procession of proopiomelanocortin in corticotroph macroadenomas.