proopiomelanocortin


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pro·o·pi·o·mel·a·no·cor·tin (POMC),

(prō-ō'pē-ō-mel'ă-nō-kōr'tin), [MIM*176830]
A large molecule found in the anterior and intermediate lobes of the pituitary gland, the hypothalamus, and other parts of the brain as well as in the lungs, gastrointestinal tract, and placenta; the precursor of ACTH, CLIP, β-LPH, γ-MSH, β-endorphin, and met-enkephalin.

POMC

A gene on chromosome 2p23 that encodes proopiomelanocortin, the melanocortin family of hormones, which include alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins bind to the melanocortin receptors, a group of five G protein-coupled receptors (MC1R to MC5R) which are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

Molecular pathology
Defects of POMC are associated with susceptibility to obesity and proopiomelanocortin deficiency.

pro·o·pi·o·mel·a·no·cor·tin

(POMC) (prō-ō'pē-ō-mel'ă-nō-kōr'tin)
A large molecule found in the anterior and intermediate lobes of the pituitary gland, the hypothalamus, and other parts of the brain as well as in the lungs, gastrointestinal tract, and placenta.

proopiomelanocortin (POMC)

The prohormone from which ACTH, beta-lipotropin, and beta-ENDORPHIN are produced by cleavage. POMC is found most abundantly in the pituitary and hypothalamus, but also occurs in the sex glands and elsewhere.
References in periodicals archive ?
Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families.
The CpG island promoter of the human proopiomelanocortin gene is methylated in nonexpressing normal tissue and tumors and represses expression.
73,75,77,89-91) Proopiomelanocortin antigens are commonly detected in melanomas, showing more intense and diffuse immunocytochemical stain in VGP.
We originally theorized that the combination of bupropion and naltrexone, the components of Contrave, would stimulate proopiomelanocortin (POMC) neuronal firing which would lead to sustained weight loss.
HMS is composed of two different populations of neurons, one set that expresses neuropeptides Y (NPY) and agouti-related protein (AgRP) and a second set that expresses proopiomelanocortin (POMC), a precursor containing a-melanocyte-stimulating hormone (Richards et al.
Leptin, an anorexogenic adipokine, stimulates the production of proopiomelanocortin products, which bind to MC4R, resulting in decreased food intake and increased energy expenditure (86).
rAAV-leptin caused an increase in STAT3 phosphorylation and proopiomelanocortin expression in the hypothalamus and an increase in uncoupling protein-1 in brown adipose tissue in both Chow and DR animals, but failed to do so in DIO.
These tumors, either through direct release or through production of precursors, preferentially express the proopiomelanocortin gene, which leads to the release of markedly higher ACTH concentrations in comparison to typical Cushing disease.
2) This interaction stimulates the anterior pituitary to produce a molecule called proopiomelanocortin (POMC), which then is processed further into smaller, biologically active peptides, including [beta]-endorphin and adrenocorticotropic hormone (ACTH).
Levels of corticotropin-releasing hormone mRNA expression in the hypothalamus and proopiomelanocortin mRNA expression in the pituitary were significantly increased, and glucocorticoid receptor protein expression in the hypothalamus paraventricular nucleus was downregulated in the depression-like model mice.
The child has a mutation of the proopiomelanocortin pathway.
Stress increases Corticotropin Releasing Factor (CRF) and Proopiomelanocortin (POCM) release.