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pronormoblast

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pronormoblast /pro·nor·mo·blast/ (-nor´mo-blast) term often considered a synonym of proerythroblast, but sometimes limited to one in a normal course of erythrocyte maturation, as opposed to a promegaloblast.
pro·nor·mo·blast (pr-nôrm-blst)
n.
The first of four stages in development of the normoblast. Also called proerythroblast, rubriblast.

pronormoblast [pro-nor´mo-blast]
a term often considered a synonym of proerythroblast; sometimes limited to one in the course of normal erythrocyte maturation, as opposed to a promegaloblast.

pronormoblast
the earliest erythrocyte precursor, having a relatively large nucleus containing several nucleoli, surrounded by a small amount of cytoplasm (see also normoblast). Called also proerythroblast and rubriblast.


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In the process of erythropoiesis, erythroid cells matures from pronormoblasts, characterised by the loss of nucleus, condensation of chromatin to form coalescent clumps, formation of siderotic clusters, and the cessation of DNA and RNA synthesis, and optimized haemoglobin production.
 
 
 
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