promyelocytic leukemia

leukemia /leu·ke·mia/ (loo-ke´me-ah) a progressive, malignant disease of the blood-forming organs, marked by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow.leuke´mic

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acute leukemia  leukemia in which the involved cell line shows little or no differentiation, usually consisting of blast cells; it comprises two types, acute lymphocytic leukemia and acute myelogenous leukemia.

acute granulocytic leukemia  acute myelogenous l.

acute lymphoblastic leukemia  (ALL) one of the two major categories of acute leukemia, characterized by anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly, and sometimes spread to the central nervous system. It is subclassified on the basis of the surface antigens expressed, e.g., B-cell type, T-cell type.

acute lymphocytic leukemia  acute lymphoblastic l.

acute megakaryoblastic leukemia , acute megakaryocytic leukemia a form of acute myelogenous leukemia in which megakaryocytes are predominant and platelets are increased in the blood.

acute monocytic leukemia  an uncommon form of acute myelogenous leukemia in which the predominating cells are monocytes.

acute myeloblastic leukemia 

1. a common type of acute myelogenous leukemia in which myeloblasts predominate; it is divided into two types on the basis of degree of cell differentiation.

2. acute myelogenous l.

acute myelocytic leukemia  acute myelogenous l.

acute myelogenous leukemia  (AML) one of the two major categories of acute leukemia, with symptoms including anemia, fatigue, weight loss, easy bruising, thrombocytopenia, and granulocytopenia.

acute myeloid leukemia 

1. acute myeloblastic l. (1).

2. acute myelogenous l.

acute myelomonocytic leukemia  a common type of acute myelogenous leukemia, with both malignant monocytes and monoblasts.

acute nonlymphocytic leukemia  acute myelogenous l.

acute promyelocytic leukemia  acute myelogenous leukemia in which more than half the cells are malignant promyelocytes.

acute undifferentiated leukemia  (AUL) acute myelogenous leukemia in which the predominating cell is so immature it cannot be classified.

adult T-cell leukemia/lymphoma  (ATL) an adult-onset, subacute or chronic malignancy of mature T lymphocytes, believed to be caused by human lymphotropic virus type I.

aleukemic leukemia  a form in which the total white blood cell count in the peripheral blood is not elevated; it may be lymphocytic, monocytic, or myelogenous.

basophilic leukemia  leukemia in which the basophilic leukocytes predominate.

chronic leukemia  leukemia in which the involved cell line is well differentiated, usually B lymphocytes, but immunologically incompetent.

chronic granulocytic leukemia  chronic leukemia of the myelogenous type, usually associated with a specific chromosomal abnormality and occurring in adulthood.

chronic lymphocytic leukemia  (CLL) chronic leukemia of the lymphoblastic type, characterized by lymphadenopathy, fatigue, renal involvement, and pulmonary leukemic infiltrates.

chronic myelocytic leukemia , chronic myelogenous leukemia, chronic myeloid leukemia chronic granulocytic l.

chronic myelomonocytic leukemia  a chronic, slowly progressing form characterized by malignant monocytes and myeloblasts, splenomegaly, and thrombocytopenia.

leukemia cu´tis  a cutaneous manifestation of leukemia resulting from infiltration of the skin by malignant leukocytes.

eosinophilic leukemia  a form in which eosinophils are the predominating cells.

granulocytic leukemia  myelogenous l.

hairy cell leukemia  chronic leukemia marked by splenomegaly and an abundance of large, mononuclear abnormal cells with numerous irregular cytoplasmic projections that give them a flagellated or hairy appearance in the bone marrow, spleen, liver, and peripheral blood.

histiocytic leukemia  acute monocytic l.

lymphatic leukemia , lymphoblastic leukemia, lymphocytic leukemia a form associated with hyperplasia and overactivity of the lymphoid tissue, with increased levels of circulating malignant lymphocytes or lymphoblasts.

lymphogenous leukemia , lymphoid leukemia lymphatic l.

lymphosarcoma cell leukemia  (B-cell type) acute lymphoblastic l.

mast cell leukemia  a rare form marked by overwhelming numbers of tissue mast cells in the peripheral blood.

megakaryoblastic leukemia  acute megakaryocytic l.

megakaryocytic leukemia 

1. acute megakaryocytic l.

2. hemorrhagic thrombocythemia.

micromyeloblastic leukemia  a form of myelogenous leukemia in which the immature nucleoli-containing cells are small and similar to lymphocytes.

monocytic leukemia  acute monocytic l.

myeloblastic leukemia 

1. myelogenous l.

2. acute myeloblastic l.

myelocytic leukemia , myelogenous leukemia, myeloid granulocytic leukemia a form arising from myeloid tissue in which the granular polymorphonuclear leukocytes and their precursors predominate. See also acute myelogenous l. and chronic granulocytic l.

myelomonocytic leukemia  acute myelomonocytic l.

plasma cell leukemia , plasmacytic leukemia a form in which the predominating cell in the peripheral blood is the plasma cell.

promyelocytic leukemia  acute promyelocytic l.

Rieder cell leukemia  a form of acute myelogenous leukemia in which the blood contains asynchronously developed cells with immature cytoplasm and a lobulated, relatively more mature nucleus.

stem cell leukemia  acute undifferentiated l.

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leukemia

a progressive, malignant disease of the blood-forming organs, marked by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Signs include fever and enlargement of the lymph nodes, spleen and liver. The persistent lymphocytosis that occurs in some cattle is a response to infection with the bovine viral leukosis virus. Similarly, leukemia may occur in the lymphoproliferative and myeloproliferative diseases caused by feline leukemia virus in cats.

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aleukemic leukemia

leukemia in which the leukocyte count is normal or below normal.

avian leukemia

see avian leukosis.

basophilic leukemia, basophilocytic leukemia

leukemia in which basophilic granulocytes predominate.

B-cell leukemia

leukemia arising from B lymphocytes.

bovine leukemia

see bovine viral leukosis.

leukemia cutis

skin lesions associated with dissemination of systemic leukemia; they may be neoplastic or nonspecific.

embryonal leukemia

stem cell leukemia.

eosinophilic leukemia

occurs rarely in cats. There are large numbers of eosinophils with infiltration of spleen, liver, lymph nodes and bone marrow.

feline leukemia complex

the array of diseases associated with infection of cats by the feline leukemia virus; includes lymphoreticular neoplasms, myelodysplastic disorders and abnormalities of the immune system.

feline leukemia virus (FeLV)

see feline leukemia virus.

granulocytic leukemia

myelocytic leukemia.

leukopenic leukemia

aleukemic leukemia.

lymphatic leukemia, lymphoblastic leukemia, lymphocytic leukemia, lymphogenous leukemia, lymphoid leukemia

leukemia associated with hyperplasia and overactivity of the lymphoid tissue, in which the leukocytes are lymphocytes or lymphoblasts.

lymphosarcoma cell leukemia

a form marked by large numbers of lymphosarcoma cells in the peripheral blood; depending on the degree of bone marrow involvement, it may be a variant of lymphosarcoma.

mast cell leukemia

a form marked by overwhelming numbers of tissue mast cells in the peripheral blood.

megakaryoblastic leukemia

a rare disease of young dogs, characterized by intestinal hemorrhage, anemia and a fatal outcome within a few weeks. There is a pancytopenia and marked thrombocytopenia.

megakaryocytic leukemia

a form with numerous megakaryocytes in the spleen, bone marrow, and other tissues, but decreased numbers or abnormal thrombocytes in the peripheral blood, and anemia. Reported in dogs and cats. Called also megakaryocytic myelosis.

monocytic leukemia

leukemia in which the predominating leukocytes are monocytes.

myeloblastic leukemia

characterized by a predominance of immature myeloid series of cells in the blood; largely a disease of young male dogs and cats.

myelocytic leukemia, myelogenous leukemia, myeloid leukemia

a form arising from myeloid tissue in which the granular polymorphonuclear leukocytes and their precursors predominate.

myelomonocytic leukemia

concurrent neoplasia of the neutrophilic and monocytic cell lines with a monocytic leukemia, a high total leukocyte count, anemia and thrombocytopenia.

plasma cell leukemia, plasmacyte leukemia

a form in which the predominating cell in the peripheral blood is the plasma cell.

premyelocytic leukemia

a form in which the predominant cells are premyeloblasts, rather than myeloblasts, often associated with abnormal bleeding secondary to thrombocytopenia, hypofibrinogenemia and decreased levels of clotting factor V.

promyelocytic leukemia

characterized by a predominance of promyelocytes in peripheral blood and in the bone marrow. A disease of dogs and cats with bleeding tendencies, anemia and a susceptibility to septicemia with a fatal outcome within a few weeks.

stem cell leukemia

leukemia in which the predominating cell is so immature and primitive that its classification is difficult.

subleukemic leukemia

aleukemic leukemia.

undifferentiated leukemia

an acute myeloproliferative disorder in which the cells involved cannot be identified.

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promyelocytic leukemia

Hematology A type of AML, a rapidly progressive CA characterized by an excess of promyelocytes in the blood and bone marrow. See Leukemia.