promyelocyte


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promyelocyte

 [pro-mi´ĕ-lo-sīt″]
a precursor in the granulocytic series, intermediate between myeloblast and myelocyte, containing a few undifferentiated cytoplasmic granules.

pro·my·e·lo·cyte

(prō-mī'ĕ-lō-sīt'),
1. The developmental stage of a granular leukocyte between the myeloblast and myelocyte, when a few specific granules appear in addition to azurophilic ones.
2. A large uninuclear cell occurring in the circulating blood of persons with myelocytic leukemia.
[pro- + G. myelos, marrow, + kytos, cell]

promyelocyte

/pro·my·elo·cyte/ (-mi´il-o-sīt″) a precursor in the granulocytic series, intermediate between myeloblast and myelocyte, containing a few, as yet undifferentiated, cytoplasmic granules.promyelocyt´ic

promyelocyte

(prō-mī′ə-lə-sīt′)
n.
A cell containing a few granules that develops from a myeloblast and develops into a myelocyte during the differentiation of a granulocyte.

promyelocyte

[prōmī′ələsīt′]
precursor in the bone marrow myelocytic series that is intermediate in development between a myeloblast and a myelocyte. The cytoplasm contains prominent primary granules. Appears in peripheral blood in acute promyelocytic leukemia.
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Promyelocyte

pro·my·e·lo·cyte

(prō-mī'ĕ-lō-sīt)
1. The developmental stage of a granular leukocyte between the myeloblast and myelocyte, when a few specific granules appear in addition to azurophilic ones.
2. A large mononuclear cell of bone marrow representing an undifferentiated stage in the development of a granulocyte, between myeloblast and myelocyte; contains only a few undifferentiated cytoplasmic granules; rare in circulating blood except in myelocytic leukemias.
Synonym(s): premyelocyte, progranulocyte.
[pro- + G. myelos, marrow, + kytos, cell]

promyelocyte

(pro-mi'el-o-sit) [Gr. pro, before, + myelos, marrow, + kytos, cell]
1. A large mononuclear myeloid cell seen in the blood in leukemia.
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PROMYELOCYTE
2. Cell development between a myeloblast and a myelocyte, resembling a myeloblast. Synonym: progranulocyte See: illustration

promyelocyte

a precursor in the granulocytic series, intermediate between myeloblast and myelocyte, containing a few, as yet undifferentiated, cytoplasmic granules.
References in periodicals archive ?
The morphology of the promyelocytes in APL shows substantial variation, and other subtypes of acute myeloid leukemia (AML) can show morphologic similarities to APL.
Antigen derived from human promyelocyte cell culture (HL-60) infected with the agent of HGE obtained from Westchester County, New York.
Antiproliferative activity of various Uncaria tomentosa preparations on HI-60 promyelocyte leukemia cells.
The discovery that all-trans retinoic acid successfully relieves the block in myeloid differentiation caused by the fusion of the retinoic acid receptor [alpha] (RAR[alpha]) gene with the promyelocyte leukemia (PML) gene in cases of acute promyelocytic leukemia led to the first example of a molecularly targeted therapy for a hematologic malignancy.
In this study we investigated the in vitro effects of resveratrol on the apoptotic cascades in human promyelocyte leukemia (HL-60) cells and first demonstrated that growth arrest- and DNA damage-induced gene 45 [alpha] (GADD45 [alpha]) and annexin A1 are involved in the apoptosis effects of resveratrol in these cells.
The latter destroys the elevated promyelocyte population, causing the promyelocytes to release granules containing procoagulants.
All stages of eosinophilic maturation can be identified, which exhibit immature eosinophilic cytoplasmic granules, mainly evident at the promyelocyte and myelocyte stages (Figure C).
For instance, it is reported that the combination of Realgar (tetraarsenic tetrasulfide), Indigo Naturalis, Radix Salviae Miltiorrhizae and Radix Pseudostellariae had exerted a synergic effect in treating human acute promyelocyte leukemia (APL) (Wang et al.
Human acute myelogenous leukemia (AML) often arises from neoplastic transformation of pluripotent stem cells, resulting in cell immaturation at the recognizable levels of myeloblast or promyelocyte stages.
Corresponding to the French-American-British morphologic category of acute myeloid leukemia M3, acute promyelocytic leukemia with recurrent t(15;17) consists of a neoplastic granulocyte population at the promyelocyte stage of maturation.
Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; APL, acute promyelocyte leukemia; B- ALL, B-cell acute lymphoblastic leukemia; CLL, chronic lymphocytic leukemia.
For example, MPO is expressed during the promyelocyte stage of granulocyte development and in mature, resting granulocytes.